PBX3 and RHEX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PBX3	RHEX
Description		PBX homeobox 3	regulator of hemoglobinization and erythroid cell expansion
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding	Erythropoietin Receptor Binding Protein Binding
	Biological Process	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	Cell Differentiation Cellular Response To Erythropoietin Erythropoietin-mediated Signaling Pathway Erythrocyte Maturation Positive Regulation Of Erythrocyte Differentiation
Pathways
Drugs
Diseases
GWAS		Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3	7 interacting genes: GAD2 GET3 PBX3 RBFA SH3GL1 SH3GLB1 SNX1
Entrez ID		5090	440712
HPRD ID		15938	17400
Ensembl ID		ENSG00000167081	ENSG00000263961
Uniprot IDs		P40426 Q5JS98 Q96AL5	Q6ZWK4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding	Posterior Compartment Specification Anterior Compartment Pattern Formation Lipid Binding Cadherin Binding Protein Localization To Vacuolar Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity GET Complex Compartment Pattern Specification Retromer, Tubulation Complex Leptin Receptor Binding 'de Novo' Post-translational Protein Folding Positive Regulation Of Membrane Tubulation Dorsal Spinal Cord Development Autophagic Cell Death Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Early Endosome Membrane Lamellipodium Morphogenesis Phosphatidylinositol 3-kinase Activator Activity Carbon-carbon Lyase Activity 'de Novo' Protein Folding
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