CPLX2 and NDRG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPLX2	NDRG4
Description		complexin 2	NDRG family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Dendrite SNARE Complex Cell Projection Neuronal Cell Body Terminal Bouton Perikaryon Calyx Of Held Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Membrane
	Molecular Function	SNARE Binding Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding	Molecular_function Protein Binding
	Biological Process	Neurotransmitter Transport Exocytosis Vesicle Docking Involved In Exocytosis Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Exocytosis Cell Differentiation Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Synaptic Plasticity Mast Cell Degranulation Modulation Of Chemical Synaptic Transmission	Heart Looping Signal Transduction Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Chronotype ( 30696823) Obesity-related traits ( 23251661)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) QT interval ( 19305408 19305409 22726844) Schizophrenia ( 29483656)
Interacting Genes		7 interacting genes: APP MYG1 NDRG4 PBX3 STX2 STX3 TSFM	37 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF BCL2L13 CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A
Entrez ID		10814	65009
HPRD ID		09234	14817
Ensembl ID		ENSG00000145920	ENSG00000103034
Uniprot IDs		Q6PUV4	A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Organelle Localization By Membrane Tethering Locomotory Behavior SNAP Receptor Activity SNARE Complex Amyloid-beta Complex Growth Cone Lamellipodium Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning SNARE Binding Posterior Compartment Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Acetylcholine Receptor Activator Activity Associative Learning Lipoprotein Particle Positive Regulation Of Protein Import Organelle Membrane Fusion Organelle Localization Vesicle Fusion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Organelle Fusion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemotaxis Anatomical Structure Morphogenesis Adult Behavior Cellular Response To Norepinephrine Stimulus Growth Cone Positive Regulation Of Synaptic Transmission Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Fusion Compartment Pattern Specification Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Synaptic Vesicle Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Formation Cytoplasmic Vesicle Endoplasmic Reticulum Tubular Network Membrane Organization Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Priming Protein Binding Regulation Of Short-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Membrane Organization
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