PBX3 and HOXA9

Number of citations of the paper that reports this interaction (PubMedID 10082572)
50

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PBX3	HOXA9
Description		PBX homeobox 3	homeobox A9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Prostate Gland Development Mammary Gland Development Response To Testosterone Embryonic Forelimb Morphogenesis Endothelial Cell Activation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Uterus Development Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS		Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)	A body shape index ( 34021172) Hypertension ( 30487518) Mean arterial pressure ( 30487518) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3	18 interacting genes: CREBBP CUL4A EIF4E JUN KRTAP10-1 KRTAP9-3 MEIS1 MEIS2 NFKBIA PBX1 PBX2 PBX3 PLSCR1 RBPMS SMAD2 SMAD4 TMEM132D TRIP6
Entrez ID		5090	3205
HPRD ID		15938	00844
Ensembl ID		ENSG00000167081	ENSG00000078399
Uniprot IDs		P40426 Q5JS98 Q96AL5	P31269
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding	Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II SMAD Protein Signal Transduction Pattern Specification Process Eye Development Negative Regulation Of Cell Differentiation Chromatin Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Sensory Organ Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Myeloid Cell Differentiation R-SMAD Binding Activin Responsive Factor Complex Brain Development Anatomical Structure Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regionalization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of Primary Metabolic Process SMAD Protein Complex Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Animal Organ Development Negative Regulation Of Neuron Differentiation Embryonic Morphogenesis Regulation Of Myeloid Cell Differentiation Nucleus
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