PBX3 and CAV3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PBX3	CAV3
Description		PBX homeobox 3	caveolin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc T-tubule Neuromuscular Junction Vesicle Protein-containing Complex Sarcolemma Membrane Raft
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding	Calcium Channel Regulator Activity Protein Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Enzyme Binding Alpha-tubulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding
	Biological Process	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	MAPK Cascade Response To Hypoxia Plasma Membrane Repair Regulation Of Heart Rate Response To Ischemia Cardiac Muscle Hypertrophy Triglyceride Metabolic Process Calcium Ion Transport Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Myotube Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Cytosolic Calcium Ion Concentration Nucleus Localization Establishment Of Localization In Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ionomycin Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis
Pathways			Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD) Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)	Caudate activity during reward ( 28927378) Takayasu arteritis ( 33308445)
Interacting Genes		65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3	21 interacting genes: ADRB2 DAG1 DYSF EGFR GNAS INSR JPH2 KCNJ12 NOS1 PBX3 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RBFA RYR1 SENP1 SLC22A11 SLC8A1 SNCA
Entrez ID		5090	859
HPRD ID		15938	03154
Ensembl ID		ENSG00000167081	ENSG00000182533
Uniprot IDs		P40426 Q5JS98 Q96AL5	P56539
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding	Regulation Of System Process Sarcolemma T-tubule Muscle System Process Regulation Of Monoatomic Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Transport Regulation Of Muscle Contraction Muscle Contraction Receptor Complex Regulation Of Metal Ion Transport System Process Negative Regulation Of Serotonin Uptake Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Regulation Of Calcium Ion Transport Regulation Of Serotonin Uptake Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Endothelial Growth Factor Binding Homeostatic Process Regulation Of Muscle System Process Sarcoplasmic Reticulum Membrane Positive Regulation Of The Force Of Heart Contraction Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Regulation Of Sequestering Of Calcium Ion Plasma Membrane Z Disc Glomerular Capillary Formation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Response To Growth Factor Positive Regulation Of Transport Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chemical Homeostasis Calcium-mediated Signaling Cellular Response To Oxygen-containing Compound Junctional Sarcoplasmic Reticulum Membrane Cellular Response To Caffeine Apical Plasma Membrane Positive Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Sarcoplasmic Reticulum Platelet-derived Growth Factor Binding Regulation Of Heart Contraction
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