PBX3 and MICOS13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PBX3	MICOS13
Description		PBX homeobox 3	mitochondrial contact site and cristae organizing system subunit 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	SAM Complex Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding	Protein Binding
	Biological Process	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	Inner Mitochondrial Membrane Organization Cristae Formation
Pathways			Cristae formation
Drugs
Diseases
GWAS		Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3	11 interacting genes: ACSF2 APOC1 APOC2 APOC4 DIABLO HSFX1 HSFX2 PBX3 RHBDD2 TEX44 UBC
Entrez ID		5090	125988
HPRD ID		15938	15198
Ensembl ID		ENSG00000167081	ENSG00000174917
Uniprot IDs		P40426 Q5JS98 Q96AL5	A0A140TA84 A0A140TA86 Q5XKP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding	High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Metabolic Process Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Negative Regulation Of Endocytosis Lipid Transport Sterol Transport Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Negative Regulation Of Lipid Metabolic Process Chylomicron Remodeling Compartment Pattern Specification Regulation Of Receptor-mediated Endocytosis Very-low-density Lipoprotein Particle Clearance Regulation Of Ketone Metabolic Process Intermediate-density Lipoprotein Particle Dorsal Spinal Cord Development Sequence-specific DNA Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Organophosphate Ester Transport
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