MTHFD2 and NAGK

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MTHFD2	NAGK
Gene Name		methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	N-acetylglucosamine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Cytosol	Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Formate-tetrahydrofolate Ligase Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Phosphate Ion Binding	Protein Binding ATP Binding N-acylmannosamine Kinase Activity N-acetylglucosamine Kinase Activity
	Biological Process	One-carbon Metabolic Process Folic Acid-containing Compound Biosynthetic Process Tetrahydrofolate Metabolic Process Oxidation-reduction Process	N-acetylglucosamine Metabolic Process N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process Carbohydrate Phosphorylation
Pathways
Drugs		Tetrahydrofolic acid NADH
Diseases
GWAS
Protein-Protein Interactions		1 interactors: NAGK	27 interactors: ACTR10 CCDC158 CDKN2C DACH1 DCP2 DYNC1I1 FGFR1OP GNPNAT1 LACTB2 LENG1 LNX1 LSM8 MEOX1 MTHFD2 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 STK16 SYNE4 TCF12 TNNT1 WDR82
Entrez ID		10797	55577
HPRD ID		05351	08441
Ensembl ID			ENSG00000124357
Uniprot IDs		P13995	C9JEV6 Q9UJ70
PDB IDs		1ZN4	2CH5 2CH6
Enriched GO Terms of Interacting Partners?		N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process N-acetylneuraminate Metabolic Process N-acetylglucosamine Metabolic Process Amino Sugar Metabolic Process Carbohydrate Phosphorylation Carboxylic Acid Catabolic Process Cellular Carbohydrate Metabolic Process
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