MTHFD2 and NAGK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		MTHFD2	NAGK
Description		methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	N-acetylglucosamine kinase
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GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Matrix	Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Catalytic Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding Oxidoreductase Activity Hydrolase Activity Phosphate Ion Binding	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity
	Biological Process	One-carbon Metabolic Process Formate Biosynthetic Process Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination
Pathways		Metabolism of folate and pterines	Synthesis of UDP-N-acetyl-glucosamine
Drugs		Tetrahydrofolic acid NADH	N-Acetylglucosamine
Diseases
GWAS			Blood protein levels ( 30072576) Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		4 interacting genes: DAPK1 LMNA NAGK PTEN	36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82
Entrez ID		10797	55577
HPRD ID		05351	08441
Ensembl ID		ENSG00000065911	ENSG00000124357
Uniprot IDs		P13995	A0A384N6G7 C9JEV6 Q9UJ70
PDB IDs		5TC4 6JIB 6JID 6KG2 6S4A 6S4E 6S4F 7EHJ 7EHM 7EHN 7EHV 9IS9 9ISC 9IT3 9IT6 9ITA	2CH5 2CH6
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Muramyl Dipeptide Kinase Activity Phosphate-containing Compound Metabolic Process Phosphorylation Cellular Response To Hydroperoxide Regulation Of Cell Communication Regulation Of Signal Transduction Postsynaptic Density Regulation Of NMDA Receptor Activity Defense Response To Tumor Cell Response To Stress Regulation Of Signaling Nuclear Lamina Negative Regulation Of Signal Transduction Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Ventricular Cardiac Muscle Cell Development Nuclear Pore Localization Regulation Of Protein Stability Negative Regulation Of Cell Communication Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Signaling Locomotor Rhythm Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization	Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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