PTGES3 and THRA

Number of citations of the paper that reports this interaction (PubMedID 10691735)
63

Data Source:
BioGRID (pull down)

		PTGES3	THRA
Description		prostaglandin E synthase 3	thyroid hormone receptor alpha
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Thyroid Hormone Binding General Transcription Initiation Factor Binding
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Receptor Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription Initiation
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	Nuclear Receptor transcription pathway
Drugs		Acetaminophen Grn163l Copper	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA	68 interacting genes: AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3
Entrez ID		10728	7067
HPRD ID		06138	07185
Ensembl ID		ENSG00000110958	ENSG00000126351
Uniprot IDs		A0A087WYT3 B3KUY2 Q15185	P10827 Q6FH41
PDB IDs		1EJF 7KRJ 7L7I 7L7J	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX 7QDT 8RQO
Enriched GO Terms of Interacting Partners?		Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Nuclear Receptor Binding Regulation Of Primary Metabolic Process Nuclear Retinoic Acid Receptor Binding Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Estrogen Receptor Binding Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Chromatin Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway DNA-templated Transcription Transcription Coactivator Activity Intracellular Signal Transduction Transcription Coregulator Activity Transcription Regulator Complex
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