PTGES3 and GZMB

Number of citations of the paper that reports this interaction (PubMedID 17283187)
39

Data Source:
BioGRID (enzymatic study)

		PTGES3	GZMB
Description		prostaglandin E synthase 3	granzyme B
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer
Drugs		Acetaminophen Grn163l Copper
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Vitiligo ( 20410501 27723757)
Interacting Genes		30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		10728	3002
HPRD ID		06138	00476
Ensembl ID		ENSG00000110958	ENSG00000100453
Uniprot IDs		A0A087WYT3 B3KUY2 Q15185	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		1EJF 7KRJ 7L7I 7L7J	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity	DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process
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