PTGES3 and AIP

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PTGES3	AIP
Description		prostaglandin E synthase 3	AHR interacting HSP90 co-chaperone
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aryl Hydrocarbon Receptor Complex
	Molecular Function	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding	Transcription Coregulator Activity Transcription Coactivator Activity Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Aryl Hydrocarbon Receptor Binding GAF Domain Binding Unfolded Protein Binding
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Positive Regulation Of DNA-templated Transcription Protein Maturation
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Acetaminophen Grn163l Copper
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528)
Interacting Genes		30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA	22 interacting genes: AHR ARNT BTG3 CEBPA CLEC7A CSNK2A1 EGFR ERBB2 GNA13 GNAQ HSP90AA1 HTR6 HUNK IKBKG IRF7 LCOR PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20
Entrez ID		10728	9049
HPRD ID		06138	10408
Ensembl ID		ENSG00000110958	ENSG00000110711
Uniprot IDs		A0A087WYT3 B3KUY2 Q15185	A0A804HJ38 A0A804HKL7 O00170
PDB IDs		1EJF 7KRJ 7L7I 7L7J	2LKN 4AIF 4APO 7ZUB 8QMO
Enriched GO Terms of Interacting Partners?		Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity	Hsp90 Protein Binding Nuclear Aryl Hydrocarbon Receptor Complex Signal Transduction Intracellular Signal Transduction Embryonic Placenta Development Protein Folding Chaperone Complex Telomerase Holoenzyme Complex Assembly Protein-containing Complex Nuclear Receptor Activity Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Positive Regulation Of Catabolic Process Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Guanyl Nucleotide Binding Protein Stabilization Ruffle Membrane Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding ERBB2 Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Unfolded Protein Binding Regulation Of Multicellular Organismal Process Maintenance Of Gastrointestinal Epithelium Protein Import Into Mitochondrial Matrix Response To Xenobiotic Stimulus Regulation Of Intracellular Signal Transduction RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation
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