DR1 and XPO1

Number of citations of the paper that reports this interaction (PMID 22833565)
7

Data Source:
BioGRID (unspecified method)

		DR1	XPO1
Gene Name		down-regulator of transcription 1, TBP-binding (negative cofactor 2)	exportin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Ran GTPase Binding Protein Transporter Activity Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Histone H3 Acetylation	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Centrosome Duplication Viral Process Viral Life Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Drug Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Loss of Function of TGFBR2 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGF-beta receptor signaling activates SMADs Influenza Life Cycle Export of Viral Ribonucleoproteins from Nucleus RNF mutants show enhanced WNT signaling and proliferation Regulation of mRNA stability by proteins that bind AU-rich elements TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Influenza Infection Late Phase of HIV Life Cycle Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Mitotic Prometaphase Separation of Sister Chromatids HIV Infection Rev-mediated nuclear export of HIV RNA G2/M Transition Mitotic Anaphase TGFBR1 LBD Mutants in Cancer HuR stabilizes mRNA deactivation of the beta-catenin transactivating complex M Phase HIV Life Cycle Rev-mediated nuclear export of HIV RNA Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN NEP/NS2 Interacts with the Cellular Export Machinery Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Interactions of Rev with host cellular proteins Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DRAP1 NFIL3 NFYC POLE3 TBP TTF2 XPO1 ZDHHC17	72 interactors: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA PXN RAN RANBP1 RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SNUPN SOX2 STAT1 STRADA TERF2IP TERT TOP2A TOP2B TP73
Entrez ID		1810	7514
HPRD ID		03284	03975
Ensembl ID			ENSG00000082898
Uniprot IDs		Q01658 Q658N3	B3KWD0 O14980
PDB IDs		1JFI	1W9C 2L1L 3GB8 4BSM 4BSN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Termination Transcription, DNA-templated RNA Biosynthetic Process Pharynx Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Ribosomal Small Subunit Export From Nucleus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Soft Palate Development Transcription From RNA Polymerase II Promoter Ribosomal Large Subunit Export From Nucleus Nitrogen Compound Metabolic Process Ribosomal Subunit Export From Nucleus Hard Palate Development Chromatin Silencing At RDNA Thyroid Hormone Generation Lipoprotein Transport Magnesium Ion Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Export From Nucleus Termination Of RNA Polymerase I Transcription Thyroid Hormone Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Thyroid Gland Development Intracellular Transport Of Virus Transcription Initiation From RNA Polymerase I Promoter Protein Palmitoylation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase I Promoter	Cell Cycle Cell Cycle Process Nucleocytoplasmic Transport Mitotic Cell Cycle Nuclear Transport Mitotic Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Organelle Organization Cytoplasmic Transport Nuclear Export Positive Regulation Of Gene Expression Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Export From Nucleus Intracellular Transport Response To Organic Substance Negative Regulation Of Phosphorylation RNA Transport RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Kinase Activity Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity RNA Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Difference) ?		cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Intersection) ?