DR1

Gene Name		down-regulator of transcription 1, TBP-binding (negative cofactor 2)
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Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Histone H3 Acetylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: DRAP1 NFIL3 NFYC POLE3 TBP TTF2 XPO1 ZDHHC17
Entrez ID		1810
HPRD ID		03284
Ensembl ID
Uniprot IDs		Q01658 Q658N3
PDB IDs		1JFI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Termination Transcription, DNA-templated RNA Biosynthetic Process Pharynx Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Ribosomal Small Subunit Export From Nucleus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Soft Palate Development Transcription From RNA Polymerase II Promoter Ribosomal Large Subunit Export From Nucleus Nitrogen Compound Metabolic Process Ribosomal Subunit Export From Nucleus Hard Palate Development Chromatin Silencing At RDNA Thyroid Hormone Generation Lipoprotein Transport Magnesium Ion Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Export From Nucleus Termination Of RNA Polymerase I Transcription Thyroid Hormone Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Thyroid Gland Development Intracellular Transport Of Virus Transcription Initiation From RNA Polymerase I Promoter Protein Palmitoylation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase I Promoter
Tagcloud ?		cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly