DR1 and ZDHHC17

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		DR1	ZDHHC17
Description		down-regulator of transcription 1	zDHHC palmitoyltransferase 17
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Negative Cofactor 2 Complex Mitotic Spindle RNA Polymerase II Transcription Regulator Complex ATAC Complex	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus
	Molecular Function	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity General Transcription Initiation Factor Activity	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development RNA Polymerase II Preinitiation Complex Assembly Regulation Of Cell Division Regulation Of Cell Cycle	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549 33339817 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528)	Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)
Interacting Genes		8 interacting genes: DNMT3L DRAP1 NFIL3 NFYC POLE3 TBP XPO1 ZDHHC17	192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		1810	23390
HPRD ID		03284	09697
Ensembl ID		ENSG00000117505	ENSG00000186908
Uniprot IDs		Q01658 Q658N3	A8KA01 Q8IUH5
PDB IDs		1JFI	3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Core Promoter Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Protein Heterodimerization Activity Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Chromatin Cellular Response To Triglyceride Negative Cofactor 2 Complex Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programing Of Female Pronucleus Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process TFIIB-class Transcription Factor Binding Response To Triglyceride Heterochromatin Formation CHRAC Leading Strand Elongation CCAAT-binding Factor Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Annulate Lamellae Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Heterochromatin Formation Epsilon DNA Polymerase Complex Negative Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Salt Ribosomal Large Subunit Export From Nucleus Protein-cysteine S-stearoyltransferase Activity	Protein Binding
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