EFNB1 and CAPN10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EFNB1	CAPN10
Description		ephrin B1	calpain 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell Surface Membrane Presynaptic Membrane Membrane Raft Synapse Extracellular Exosome Glutamatergic Synapse	Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protein Binding Ephrin Receptor Binding	SNARE Binding Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Nervous System Development Axon Guidance Embryonic Pattern Specification Cell Differentiation T Cell Costimulation T Cell Proliferation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Autophagosome Assembly	Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Insulin Secretion Positive Regulation Of Intracellular Transport Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of D-glucose Import Type B Pancreatic Cell Apoptotic Process Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Degradation of the extracellular matrix
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome	Type II diabetes mellitus
GWAS
Interacting Genes		17 interacting genes: ANKRD46 CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ	5 interacting genes: EFNB1 FANCC FLOT1 PSMA7 SHD
Entrez ID		1947	11132
HPRD ID		02072	05595
Ensembl ID		ENSG00000090776	ENSG00000142330
Uniprot IDs		P98172	Q9HC96
PDB IDs		6THG
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Dendritic Spine Development Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Cell Junction Assembly Dendritic Spine Organization Signaling Receptor Complex Adaptor Activity Cell Recognition Protein Tyrosine Kinase Activity Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Neuron Projection Organization Postsynapse Organization Signal Transduction Cell Migration Cell-substrate Adhesion Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cell Projection Organization Plasma Membrane Cytosol Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Phosphorylation Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Cell Motility Positive Regulation Of Protein Localization To Plasma Membrane Actin Filament Bundle Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Cell Projection Organization Membrane Raft Axon Guidance Receptor Activity Fibroblast Apoptotic Process Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Cell Migration In Hindbrain Positive Regulation Of Protein Localization To Membrane
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