EFNB1 and EPHB1

Number of citations of the paper that reports this interaction (PubMedID 10669731)
55

Data Source:
HPRD (in vitro, in vivo)

		EFNB1	EPHB1
Description		ephrin B1	EPH receptor B1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell Surface Membrane Presynaptic Membrane Membrane Raft Synapse Extracellular Exosome Glutamatergic Synapse	Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Cell Projection Membrane Raft Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Ephrin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Protein-containing Complex Binding
	Biological Process	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Nervous System Development Axon Guidance Embryonic Pattern Specification Cell Differentiation T Cell Costimulation T Cell Proliferation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Autophagosome Assembly	Angiogenesis Immunological Synapse Formation Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Skeletal Muscle Satellite Cell Activation Cell Migration Cranial Nerve Development Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis System Development Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Chlortetracycline Fostamatinib
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS			A body shape index ( 34021172) Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		17 interacting genes: ANKRD46 CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ	13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN
Entrez ID		1947	2047
HPRD ID		02072	02790
Ensembl ID		ENSG00000090776	ENSG00000154928
Uniprot IDs		P98172	P54762
PDB IDs		6THG	2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW 7KPL 7KPM
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Dendritic Spine Development Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Cell Junction Assembly Dendritic Spine Organization Signaling Receptor Complex Adaptor Activity Cell Recognition Protein Tyrosine Kinase Activity Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Neuron Projection Organization Postsynapse Organization Signal Transduction Cell Migration Cell-substrate Adhesion Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cell Projection Organization Plasma Membrane Cytosol Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Phosphorylation Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Cell Motility Positive Regulation Of Protein Localization To Plasma Membrane Actin Filament Bundle Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Cell Projection Organization Membrane Raft Axon Guidance Receptor Activity Fibroblast Apoptotic Process Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Cell Migration In Hindbrain Positive Regulation Of Protein Localization To Membrane	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Signaling Pathway Vesicle Membrane Acid Phosphatase Activity Neuron Projection Development Neurotrophin TRKA Receptor Binding T Cell Costimulation T Cell Activation Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Pyrimidine-containing Compound Metabolic Process T Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cell-cell Junction Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Schwann Cell Development Lymphocyte Activation Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Cell Projection Organization Positive Regulation Of Cell Adhesion Lymphocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Mononuclear Cell Proliferation Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Presynaptic Membrane Leukocyte Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Insulin-like Growth Factor Receptor Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lymphocyte Activation Regulation Of Actin Cytoskeleton Organization Thiamine Phosphate Phosphatase Activity Signal Transduction Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity
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