EFNB1 and EPHB2

Number of citations of the paper that reports this interaction (PMID 8878483)
89

Data Source:
HPRD (in vitro, in vivo)

		EFNB1	EPHB2
Gene Name		ephrin-B1	EPH receptor B2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Synapse Extracellular Vesicular Exosome	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Binding Ephrin Receptor Binding	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Axon Guidance Embryonic Pattern Specification Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ	36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1
Entrez ID		1947	2048
HPRD ID		02072	02997
Ensembl ID		ENSG00000090776	ENSG00000133216
Uniprot IDs		P98172	P29323
PDB IDs			1B4F 1F0M 2QBX
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Axon Guidance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Neuron Projection Development Axonogenesis Cell Development Axon Development Regulation Of Organelle Organization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Stress Fiber Assembly Cell Morphogenesis Generation Of Neurons Dendritic Spine Organization Neurogenesis Nervous System Development Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Signal Transduction Cell Motility Cellular Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Apoptotic Process Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Signaling Programmed Cell Death Actin Filament-based Process Cell Communication Cell Death Death Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Organelle Organization Positive Regulation Of Transport Anatomical Structure Morphogenesis Optic Nerve Morphogenesis	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process
Tagcloud ?		allow attenuation cetuximab contribution dimerization disappointing drives egf egfr ephrinb1 erbb1 head hnscc mechanistically mediate neck overexpress partner partners persistent persists rearrangements shift slowed squamous substantial targeted trigger yielded	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Difference) ?		allow attenuation cetuximab contribution dimerization disappointing drives egf egfr ephrinb1 erbb1 head hnscc mechanistically mediate neck overexpress partner partners persistent persists rearrangements shift slowed squamous substantial targeted trigger yielded	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Intersection) ?