EFNB1 and PTPN13

Number of citations of the paper that reports this interaction (PubMedID 9920925)
0

Data Source:
HPRD (in vitro, in vivo)

		EFNB1	PTPN13
Description		ephrin B1	protein tyrosine phosphatase non-receptor type 13
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell Surface Membrane Presynaptic Membrane Membrane Raft Synapse Extracellular Exosome Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Ephrin Receptor Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Nervous System Development Axon Guidance Embryonic Pattern Specification Cell Differentiation T Cell Costimulation T Cell Proliferation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Autophagosome Assembly	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Toxic Substance Negative Regulation Of Excitatory Synapse Assembly
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS			Appendicular lean mass ( 33097823) Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Tinnitus ( 33742053) Word spelling ( 30741946)
Interacting Genes		17 interacting genes: ANKRD46 CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ	26 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 DSCAM EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 VANGL2 YWHAZ
Entrez ID		1947	5783
HPRD ID		02072	02602
Ensembl ID		ENSG00000090776	ENSG00000163629
Uniprot IDs		P98172	Q12923
PDB IDs		6THG	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ 7QCX 7QCY 7XTY
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Dendritic Spine Development Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Cell Junction Assembly Dendritic Spine Organization Signaling Receptor Complex Adaptor Activity Cell Recognition Protein Tyrosine Kinase Activity Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Neuron Projection Organization Postsynapse Organization Signal Transduction Cell Migration Cell-substrate Adhesion Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cell Projection Organization Plasma Membrane Cytosol Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Phosphorylation Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Cell Motility Positive Regulation Of Protein Localization To Plasma Membrane Actin Filament Bundle Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Cell Projection Organization Membrane Raft Axon Guidance Receptor Activity Fibroblast Apoptotic Process Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Cell Migration In Hindbrain Positive Regulation Of Protein Localization To Membrane	Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Protein Phosphatase Binding Glutamatergic Synapse Neuron Projection Guidance Axon Guidance Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction CD95 Death-inducing Signaling Complex Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cell Junction Assembly Positive Regulation Of Cell Population Proliferation Tube Formation Death-inducing Signaling Complex Cell Junction Organization Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Regulation Of Intracellular Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Population Proliferation Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Cellular Developmental Process Cell-cell Junction Organization Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Beta-catenin Destruction Complex Positive Regulation Of Apoptotic Process Lateral Plasma Membrane Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Rho Protein Signal Transduction Wnt Signalosome Adherens Junction Nervous System Development Lamellipodium
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