Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
POLR2M and PSMC2
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
POLR2M
PSMC2
Gene Name
polymerase (RNA) II (DNA directed) polypeptide M
proteasome (prosome, macropain) 26S subunit, ATPase, 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Envelope
DNA-directed RNA Polymerase II, Holoenzyme
Neuronal Cell Body
Proteasome Complex
Cytoplasmic MRNA Processing Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Proteasome Accessory Complex
Molecular Function
DNA-directed RNA Polymerase Activity
Protein Binding
ATP Binding
ATPase Activity
Biological Process
RNA Biosynthetic Process
Maintenance Of ER Location
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Osteoblast Differentiation
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
19 interactors:
AHSP
ANKHD1
APOD
CEBPG
DGKZ
HIGD1B
KIAA1377
MYO3A
MYO9A
NEDD4
PSMC2
RBM4B
RPL7A
SCMH1
SIVA1
THAP1
UQCRQ
WDR89
ZNF410
17 interactors:
GTF2B
GTF2F1
GTF2H1
NDC80
NDRG1
POLR2M
PSMC1
PSMC4
PSMD2
PSMD4
PSMD5
SKIL
SUMO4
TBP
TRAF6
TRIM5
UBC
Entrez ID
81488
5701
HPRD ID
07575
01105
Ensembl ID
ENSG00000255529
ENSG00000161057
Uniprot IDs
P0CAP1
P0CAP2
Q6EEV4
B7Z571
P35998
PDB IDs
2KXS
Enriched GO Terms of Interacting Partners
?
Viral Process
Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Negative Regulation Of T Cell Migration
Negative Regulation Of Lipoprotein Lipid Oxidation
Transmission Of Virus
Development Involved In Symbiotic Interaction
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Negative Regulation Of Smooth Muscle Cell-matrix Adhesion
Subthalamus Development
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Lipoprotein Lipid Oxidation
Mitotic DNA Damage Checkpoint
Regulation Of Smooth Muscle Cell-matrix Adhesion
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint
Interaction With Host
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Lymphocyte Migration
Regulation Of Intracellular Transport
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Progesterone Receptor Signaling Pathway
Developmental Process
Viral Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Polyubiquitination
Signal Transduction In Response To DNA Damage
Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Positive Regulation Of Protein Ubiquitination
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Regulation Of Protein Ubiquitination
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint
Negative Regulation Of Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Positive Regulation Of Cell Cycle Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Peptide Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Antigen Processing And Presentation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cellular Protein Catabolic Process
DNA Damage Checkpoint
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Positive Regulation Of Wnt Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Checkpoint
Transcription Initiation From RNA Polymerase II Promoter
Tagcloud
?
11p11
12q15
17q23
19p13
19q13
20s
26s
7q22
atpases
charges
consitute
machine
modules
mss1
multisubunit
p42
pa700
proteasome
psmc1
psmc3
psmc4
psmc5
psmc6
q13
q22
q23
s4
tbp1
tbp7
Tagcloud (Difference)
?
11p11
12q15
17q23
19p13
19q13
20s
26s
7q22
atpases
charges
consitute
machine
modules
mss1
multisubunit
p42
pa700
proteasome
psmc1
psmc3
psmc4
psmc5
psmc6
q13
q22
q23
s4
tbp1
tbp7
Tagcloud (Intersection)
?