ARL6 and CRYBG3

		ARL6	CRYBG3
Description		ARF like GTPase 6	crystallin beta-gamma domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Membrane Coat Cell Projection Extracellular Exosome	Protein-containing Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Structural Constituent Of Eye Lens Carbohydrate Binding Protein Kinase A Binding
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Protein Transport Wnt Signaling Pathway Vesicle-mediated Transport Cell Projection Organization Melanosome Transport Fat Cell Differentiation Protein Polymerization Cilium Assembly Protein Localization To Cilium Protein Localization To Non-motile Cilium Protein Transport From Ciliary Membrane To Plasma Membrane	Lens Development In Camera-type Eye Visual Perception
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Male infertility ( 19478329)
Interacting Genes		6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B
Entrez ID		84100	131544
HPRD ID		10588	19091
Ensembl ID		ENSG00000113966	ENSG00000080200
Uniprot IDs		Q9H0F7	Q68DQ2
PDB IDs		2H57
Enriched GO Terms of Interacting Partners?		Regulation Of L-glutamate Import Across Plasma Membrane Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Cellular Localization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Organization Negative Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Amine Transport	Protein Localization To Non-motile Cilium Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Protein Localization To Cilium Axoneme Protein Transport From Ciliary Membrane To Plasma Membrane Cilium Organization GTPase Activity Protein Localization To Cell Periphery Cilium Assembly Microtubule Cytoskeleton Protein Localization To Membrane Receptor Localization To Non-motile Cilium Cell Projection Assembly GTP Binding Plasma Membrane Bounded Cell Projection Assembly Formation Of Radial Glial Scaffolds Pattern Specification Process Localization Within Membrane Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Cilium Protein Localization To Organelle Left/right Axis Specification Organelle Assembly Establishment Of Melanosome Localization Melanosome Localization Plasma Membrane Bounded Cell Projection Organization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Retina Layer Formation Membrane Coat Non-motile Cilium Axonemal Microtubule Cell Projection Organization Telencephalon Cell Migration Cell Projection Forebrain Cell Migration Non-motile Cilium Assembly Ciliary Membrane Establishment Of Protein Localization To Plasma Membrane Cytoskeleton Heart Looping Protein Targeting To Membrane Cellular Localization Dorsal/ventral Pattern Formation Embryonic Heart Tube Morphogenesis Protein Polymerization
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