PGRMC2 and GPR151

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	GPR151
Description		progesterone receptor membrane component 2	G protein-coupled receptor 151
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Plasma Membrane Membrane Synaptic Vesicle Membrane Presynaptic Membrane Cholinergic Synapse
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	Response To Ischemia Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Acidic PH Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	42 interacting genes: APOD AQP6 ARL6IP1 BCL2L2 C1GALT1 CD300C CDIPT CERS4 CGRRF1 CREB3L1 CYBC1 EFNA5 ERGIC3 FAM209A GAL GJA8 GPR152 GPX8 IGFBP5 KEAP1 LAT MANBAL NRM PGRMC2 PLP2 SACM1L SCN3B SHISAL1 SLC10A1 SLC10A6 SLC18A1 SLC18A2 SLC41A2 SSMEM1 STX8 TIMMDC1 TMBIM6 TMEM179B TMEM239 TMEM31 TRARG1 UNC93A
Entrez ID		10424	134391
HPRD ID		09665	17065
Ensembl ID		ENSG00000164040	ENSG00000173250
Uniprot IDs		O15173	Q8TDV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	Membrane Endoplasmic Reticulum Aminergic Neurotransmitter Loading Into Synaptic Vesicle Transmembrane Transport Serotonin:sodium:chloride Symporter Activity Monoamine:proton Antiporter Activity Monoatomic Ion Transport Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Neurotransmitter Loading Into Synaptic Vesicle Endoplasmic Reticulum Membrane Serotonin Uptake Monoamine Transmembrane Transporter Activity Amine Transport Monoatomic Cation Transport Serotonin Transport Protein Binding Organic Hydroxy Compound Transport
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