PGRMC2 and FAXDC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	FAXDC2
Description		progesterone receptor membrane component 2	fatty acid hydroxylase domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	C-4 Methylsterol Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	Positive Regulation Of Protein Phosphorylation Lipid Biosynthetic Process Sterol Biosynthetic Process Positive Regulation Of Megakaryocyte Differentiation
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	33 interacting genes: AQP6 ARL13B CD79A CGRRF1 CLDN7 CREB3L1 CYB5R3 EBP ELOVL4 ERGIC3 FCER1G FFAR2 GOLT1A GPR152 GPX8 HSD17B13 LMNA MGST3 NEMP1 PANX1 PGRMC2 RETREG3 SLC10A1 SLC10A6 SLC30A8 STOM STX4 TMEM106C TMEM139 TMEM31 TMEM86B TMPRSS2 TMX2
Entrez ID		10424	10826
HPRD ID		09665	12832
Ensembl ID		ENSG00000164040	ENSG00000170271
Uniprot IDs		O15173	Q96IV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Nuclear Envelope Bile Acid:sodium Symporter Activity Monoatomic Anion Channel Activity Protein Binding
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