PGRMC2 and TAS2R19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	TAS2R19
Description		progesterone receptor membrane component 2	taste 2 receptor member 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Plasma Membrane Membrane
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	G Protein-coupled Receptor Activity Protein Binding Bitter Taste Receptor Activity
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	7 interacting genes: LNPEP MMGT1 PGRMC2 PVR TMEM14B TMEM167B TYW1B
Entrez ID		10424	259294
HPRD ID		09665	18156
Ensembl ID		ENSG00000164040	ENSG00000212124
Uniprot IDs		O15173	P59542
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Iron Ion Transport TRNA-4-demethylwyosine Synthase Activity Susceptibility To T Cell Mediated Cytotoxicity Cobalt Ion Transmembrane Transporter Activity Early Endosome Lumen Neuropeptide Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Susceptibility To Natural Killer Cell Mediated Cytotoxicity Heme Transmembrane Transporter Activity Heme Transport Constitutive Secretory Pathway Inorganic Cation Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Wybutosine Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence EMC Complex Cobalt Ion Transport
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