PGRMC2 and SFXN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	SFXN1
Description		progesterone receptor membrane component 2	sideroflexin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	Protein Binding Monoatomic Ion Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	One-carbon Metabolic Process Monoatomic Ion Transport Iron Ion Transport Amino Acid Transport L-alanine Transport L-serine Transport Erythrocyte Differentiation Monoatomic Ion Transmembrane Transport Transmembrane Transport Serine Import Into Mitochondrion
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)	Height ( 28552196) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	14 interacting genes: AQP6 CIDEB FCER1G HSD17B13 MMD PGRMC2 SCN3B SLC10A1 SLC10A6 SLC16A7 STOM TLCD4 TMEM14B TMX2
Entrez ID		10424	94081
HPRD ID		09665	18044
Ensembl ID		ENSG00000164040	ENSG00000164466
Uniprot IDs		O15173	Q9H9B4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Membrane Symporter Activity Bile Acid And Bile Salt Transport Monocarboxylic Acid Transport Sodium Ion Transport Nitrate Transmembrane Transporter Activity Monoatomic Ion Transport Endoplasmic Reticulum IgE Receptor Activity Pyruvate Secondary Active Transmembrane Transporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Transmembrane Transport Tertiary Granule Membrane Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Carboxylic Acid Transport Organic Acid Transport Metal Ion Transport Secondary Active Monocarboxylate Transmembrane Transporter Activity Identical Protein Binding Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity Monoatomic Cation Transport Lipid Transport Organic Anion Transport Lipid Droplet Steroid Dehydrogenase Activity Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Pyruvate Transmembrane Transporter Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Lipid Droplet Fusion Lactate Transmembrane Transporter Activity Pyruvate Transport SA Node Cell Action Potential
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