PGRMC2 and GHITM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	GHITM
Description		progesterone receptor membrane component 2	growth hormone inducible transmembrane protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Extracellular Exosome
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	Calcium Channel Activity Protein Binding Calcium:proton Antiporter Activity
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	Calcium Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Apoptotic Process Inner Mitochondrial Membrane Organization Negative Regulation Of Release Of Cytochrome C From Mitochondria Calcium Export From The Mitochondrion Mitochondrial Potassium Ion Transmembrane Transport Proton Transmembrane Transport Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)	Abstraction and mental flexibility ( 31596458) Influenza A (H1N1) infection ( 26379185) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185) Refractive error ( 32231278)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	13 interacting genes: AGTR1 CCR4 DRD2 FAM209A FXYD3 GPR35 GPR37 HTR2C HTR4 JSRP1 PGRMC2 SLC22A1 TMEM242
Entrez ID		10424	27069
HPRD ID		09665	17038
Ensembl ID		ENSG00000164040	ENSG00000165678
Uniprot IDs		O15173	Q9H3K2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Catecholamine Uptake Dopamine Uptake Serotonin Binding Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Monoatomic Cation Transport G Protein-coupled Serotonin Receptor Activity Interneuron Migration Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Set1C/COMPASS Complex Neurotransmitter Receptor Activity Dopamine Transport Neurotransmitter Reuptake Monoatomic Ion Transport G Protein-coupled Serotonin Receptor Signaling Pathway Chemokine Receptor Activity Metal Ion Transport Regulation Of Appetite Regulation Of Sequestering Of Calcium Ion Monoamine Transport Neurotransmitter Uptake Dopamine Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Angiotensin Type I Receptor Activity Calcium Ion Transmembrane Transport Catecholamine Metabolic Process Large Intestinal Transit Dendrite Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signaling Cassette Bradykinin Receptor Binding G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Prosaposin Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding (R)-carnitine Transmembrane Transport Pyrimidine Nucleoside Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity
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