GPR151 and SLC18A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR151	SLC18A2
Description		G protein-coupled receptor 151	solute carrier family 18 member A2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synaptic Vesicle Membrane Presynaptic Membrane Cholinergic Synapse	Centrosome Plasma Membrane Synaptic Vesicle Membrane Axon Dendrite Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Dopaminergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity
	Biological Process	Response To Ischemia Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Acidic PH Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis	Response To Amphetamine Serotonin Secretion By Mast Cell Histamine Secretion By Mast Cell Neurotransmitter Transport Serotonin Transport Chemical Synaptic Transmission Locomotory Behavior Response To Toxic Substance Post-embryonic Development Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Serotonin Uptake Histamine Uptake Establishment Of Localization In Cell Transmembrane Transport Neurotransmitter Loading Into Synaptic Vesicle Somato-dendritic Dopamine Secretion Proton Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs			Amphetamine Reserpine Norepinephrine Haloperidol Mazindol Benzphetamine Dopamine Deserpidine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Nomifensine Tetrabenazine Histamine Isometheptene Propylhexedrine Serotonin Rauwolfia serpentina root Deutetrabenazine
Diseases
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Body mass index ( 26426971) Retinopathy x type 2 diabetes interaction ( 32541925) Serum metabolite levels ( 33031748)
Interacting Genes		42 interacting genes: APOD AQP6 ARL6IP1 BCL2L2 C1GALT1 CD300C CDIPT CERS4 CGRRF1 CREB3L1 CYBC1 EFNA5 ERGIC3 FAM209A GAL GJA8 GPR152 GPX8 IGFBP5 KEAP1 LAT MANBAL NRM PGRMC2 PLP2 SACM1L SCN3B SHISAL1 SLC10A1 SLC10A6 SLC18A1 SLC18A2 SLC41A2 SSMEM1 STX8 TIMMDC1 TMBIM6 TMEM179B TMEM239 TMEM31 TRARG1 UNC93A	14 interacting genes: BRICD5 CFHR5 CMTM5 CSNK1A1 CSNK2A1 CSNK2A2 CXCR2 DNAJC5 GPR151 NKG7 SLC61A1 SLC7A1 TMEM109 TOMM6
Entrez ID		134391	6571
HPRD ID		17065	01896
Ensembl ID		ENSG00000173250	ENSG00000165646
Uniprot IDs		Q8TDV0	Q05940
PDB IDs			8JSW 8JSX 8JT5 8JT9 8JTA 8JTB 8JTC 8T69 8T6A 8T6B 8THR 8UCJ 8UCK 8UCL 8UCM 8UCN 8UCO 8UCP 8WLJ 8WLK 8WLL 8WLM 8WRD 8WRE 8WVG 8X3K 8XO9 8XOA 8XOB 9KQ8 9KQA 9KQE
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Aminergic Neurotransmitter Loading Into Synaptic Vesicle Transmembrane Transport Serotonin:sodium:chloride Symporter Activity Monoamine:proton Antiporter Activity Monoatomic Ion Transport Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Neurotransmitter Loading Into Synaptic Vesicle Endoplasmic Reticulum Membrane Serotonin Uptake Monoamine Transmembrane Transporter Activity Amine Transport Monoatomic Cation Transport Serotonin Transport Protein Binding Organic Hydroxy Compound Transport	Protein Kinase CK2 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PcG Protein Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Response To Stress Interleukin-8 Receptor Activity Interleukin-8-mediated Signaling Pathway Lysine Transport L-histidine Import Across Plasma Membrane Regulation Of Chromosome Separation
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