PGRMC2 and CYB561D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	CYB561D2
Description		progesterone receptor membrane component 2	cytochrome b561 family member D2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	Transmembrane Transport Ascorbate Homeostasis
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	26 interacting genes: APP ARL13B BIK CD79A CLDN7 CLEC14A CLNK COQ9 CREB3L1 CYB5R3 ERGIC3 FAM209A FKBP7 GPX8 LMNA PDE4A PGRMC2 PSCA PTPN5 RMDN3 SLC18A1 SLC30A2 TIMMDC1 TMEM154 TMEM45B UNC119
Entrez ID		10424	11068
HPRD ID		09665	06143
Ensembl ID		ENSG00000164040	ENSG00000114395
Uniprot IDs		O15173	O14569
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	Membrane
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