PGRMC2 and TMEM86A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC2	TMEM86A
Description		progesterone receptor membrane component 2	transmembrane protein 86A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding	Protein Binding Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
	Biological Process	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development	Lipid Metabolic Process
Pathways		RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)	Ovarian reserve ( 22116950)
Interacting Genes		55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1	48 interacting genes: AQP2 AQP3 BCL2L13 CD79A CISD2 CNR2 COQ9 CPLX4 CREB3L1 EBP ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 FXYD3 GJB4 GJB5 GJC1 GORAB GPR37L1 GPX8 HAVCR2 KASH5 KCNA1 LHFPL5 LMNA MS4A2 MUC1 NCAPH2 PDZK1IP1 PGRMC2 PI16 REEP4 RIC3 RNF185 SCN3B SLC10A6 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SSMEM1 THAP4 TIMMDC1 TMEM31 TMPRSS2 TYROBP
Entrez ID		10424	144110
HPRD ID		09665	08292
Ensembl ID		ENSG00000164040	ENSG00000151117
Uniprot IDs		O15173	Q8N2M4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin	Membrane Transmembrane Transport Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Glycerol Transmembrane Transport Monoatomic Ion Transport Renal Water Transport Endoplasmic Reticulum Polyol Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Transport Vesicle Membrane
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