PDGFRA and SNX4

Number of citations of the paper that reports this interaction (PubMedID 9819414)
41

Data Source:
HPRD (in vivo)

		PDGFRA	SNX4
Description		platelet derived growth factor receptor alpha	sorting nexin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Protein-containing Complex Cell Projection Receptor Complex Platelet-derived Growth Factor Receptor-ligand Complex	Cytoplasm Endosome Early Endosome Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex Presynaptic Endosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Female Gonad Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Platelet Activation Cell Migration Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Regulation Of Actin Cytoskeleton Organization Leydig Cell Differentiation Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Calcium-mediated Signaling White Fat Cell Differentiation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Mesenchymal Stem Cell Differentiation	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Tivozanib Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases		Glioma
GWAS		Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 29422769 22144915) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 28453575 29403010 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)
Interacting Genes		62 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR ERBB2 ERBB3 FBXO25 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 NHERF1 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2	18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SUPT5H
Entrez ID		5156	8723
HPRD ID		01429	09334
Ensembl ID		ENSG00000134853	ENSG00000114520
Uniprot IDs		P16234	O95219
PDB IDs		1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL 7LBF 7RAM 8PQH 8PQI 8PQJ 8PQK 9GZH
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Developmental Process Cellular Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Cell Differentiation Animal Organ Development Negative Regulation Of Cell Differentiation Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Migration Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Motility Regulation Of Cell Development Response To Epidermal Growth Factor Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process	Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Autophagy Receptor Complex Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Protein Tyrosine Kinase Activity Glomerular Capillary Formation Lipid Binding Regulation Of Macroautophagy Platelet-derived Growth Factor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Regulation Of Glucose Metabolic Process Cellular Response To Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Endosome Membrane Membrane Retromer Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Response To Growth Factor Adrenal Gland Development Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Myofibril Assembly Negative Regulation Of ERBB Signaling Pathway Cellular Localization Negative Regulation Of Catabolic Process Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Endosome Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Organelle Organization Protein-containing Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Leptin Receptor Activity Platelet-derived Growth Factor Alpha-receptor Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
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