PDGFRA and SNX4

Number of citations of the paper that reports this interaction (PMID 9819414)
60

Data Source:
HPRD (in vivo)

		PDGFRA	SNX4
Gene Name		platelet-derived growth factor receptor, alpha polypeptide	sorting nexin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Membrane Intrinsic Component Of Plasma Membrane	Cytoplasm Cytoplasmic Dynein Complex Plasma Membrane Membrane Extrinsic Component Of Membrane SNARE Complex Early Endosome Membrane Protein Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Platelet-derived Growth Factor Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Estrogen Metabolic Process Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Chemotaxis Cardiac Myofibril Assembly Palate Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation	Protein Transport Vesicle Organization Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Becaplermin Imatinib Sunitinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Corneal astigmatism ( 22144915) Corneal curvature ( 23401653 21665993) Height ( 18193045) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		31 interactors: CAV1 CAV3 CBL CCDC155 CRK CRKL FBXO25 GRB14 ITGAV ITGB3 JAK1 PDGFA PDGFB PDGFC PDGFRB PIK3R1 PLCG1 PTPN11 SHB SHF SLC9A3R1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B TGFBR2 ULBP2	15 interactors: AGK ARL6IP1 ATP6V0A1 BIN1 EGFR HIVEP1 INSR LEPR MAGEA6 PDGFRA PDGFRB PTPN5 SNX2 SNX6 SUPT5H
Entrez ID		5156	8723
HPRD ID		01429	09334
Ensembl ID		ENSG00000134853	ENSG00000114520
Uniprot IDs		P16234	O95219
PDB IDs		1GQ5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signaling Regulation Of Signal Transduction Immune System Process Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Blood Coagulation Positive Regulation Of Protein Metabolic Process Hemostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune System Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Leukocyte Migration Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Protein Phosphorylation Response To Hormone Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of Phospholipase C Activity Glomerular Capillary Formation Protein Autophosphorylation Positive Regulation Of DNA Replication Metanephric Glomerulus Vasculature Development Positive Regulation Of Phospholipase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Peptidyl-tyrosine Phosphorylation Metanephric Glomerulus Development Glomerulus Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Retina Vasculature Development In Camera-type Eye Glomerulus Vasculature Development Cardiac Myofibril Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Platelet-derived Growth Factor Regulation Of Kinase Activity Digestive System Development Regulation Of Reactive Oxygen Species Metabolic Process Vascular Endothelial Growth Factor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Adrenal Gland Development Metanephric Nephron Development Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity
Tagcloud ?		address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Difference) ?		address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Intersection) ?