PDGFRA and SNX2

Number of citations of the paper that reports this interaction (PMID 9819414)
60

Data Source:
HPRD (in vitro, in vivo)

		PDGFRA	SNX2
Gene Name		platelet-derived growth factor receptor, alpha polypeptide	sorting nexin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Membrane Intrinsic Component Of Plasma Membrane	Cytoplasm Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Platelet-derived Growth Factor Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Estrogen Metabolic Process Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Chemotaxis Cardiac Myofibril Assembly Palate Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation	Intracellular Protein Transport Endocytosis Vesicle Organization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Protein Oligomerization Lamellipodium Morphogenesis
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		Becaplermin Imatinib Sunitinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Corneal astigmatism ( 22144915) Corneal curvature ( 23401653 21665993) Height ( 18193045) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		31 interactors: CAV1 CAV3 CBL CCDC155 CRK CRKL FBXO25 GRB14 ITGAV ITGB3 JAK1 PDGFA PDGFB PDGFC PDGFRB PIK3R1 PLCG1 PTPN11 SHB SHF SLC9A3R1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B TGFBR2 ULBP2	20 interactors: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202
Entrez ID		5156	6643
HPRD ID		01429	09332
Ensembl ID		ENSG00000134853	ENSG00000205302
Uniprot IDs		P16234	B4DEK4 B7Z408 O60749
PDB IDs		1GQ5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signaling Regulation Of Signal Transduction Immune System Process Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Blood Coagulation Positive Regulation Of Protein Metabolic Process Hemostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune System Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Leukocyte Migration Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Protein Phosphorylation Response To Hormone Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Migration Positive Regulation Of Locomotion Protein Phosphorylation Regulation Of Cell Motility Phosphorylation Regulation Of Signaling Retina Vasculature Development In Camera-type Eye Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Tissue Development Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of DNA Metabolic Process Digestive System Development Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Glomerular Capillary Formation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Retrograde Transport, Endosome To Golgi Tube Morphogenesis Endosomal Transport Metanephric Glomerulus Vasculature Development Digestive Tract Morphogenesis
Tagcloud ?		address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore	assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Difference) ?		address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore	assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Intersection) ?