PDGFRA and PDGFB

Number of citations of the paper that reports this interaction (PubMedID 2544881)
32

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PDGFRA	PDGFB
Description		platelet derived growth factor receptor alpha	platelet derived growth factor subunit B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Protein-containing Complex Cell Projection Receptor Complex Platelet-derived Growth Factor Receptor-ligand Complex	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cell Surface Membrane Basolateral Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding
	Biological Process	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Female Gonad Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Platelet Activation Cell Migration Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Regulation Of Actin Cytoskeleton Organization Leydig Cell Differentiation Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Calcium-mediated Signaling White Fat Cell Differentiation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Mesenchymal Stem Cell Differentiation	Angiogenesis Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Positive Regulation Of Glomerular Filtration Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Response To Wounding Gene Expression Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Paracrine Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs	Platelet degranulation PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Tivozanib Fostamatinib Erdafitinib Amuvatinib Ripretinib	Pegpleranib
Diseases		Glioma	Glioma Malignant pleural mesothelioma
GWAS		Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 29422769 22144915) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 28453575 29403010 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000)
Interacting Genes		62 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR ERBB2 ERBB3 FBXO25 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 NHERF1 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2	23 interacting genes: A2M ART1 BCCIP COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 FBXO7 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB PIK3R1 SPARC THBS1
Entrez ID		5156	5155
HPRD ID		01429	01815
Ensembl ID		ENSG00000134853	ENSG00000100311
Uniprot IDs		P16234	A0A384NYY3 P01127
PDB IDs		1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL 7LBF 7RAM 8PQH 8PQI 8PQJ 8PQK 9GZH	1PDG 3MJG 4HQU 4HQX 4QCI 6T9E
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Developmental Process Cellular Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Cell Differentiation Animal Organ Development Negative Regulation Of Cell Differentiation Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Migration Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Motility Regulation Of Cell Development Response To Epidermal Growth Factor Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process	Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Extracellular Matrix Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Basement Membrane Anatomical Structure Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Amino Acid Stimulus Phospholipase C Activator Activity Regulation Of Locomotion Response To Amino Acid Enzyme-linked Receptor Protein Signaling Pathway Animal Organ Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Extracellular Region Protease Binding Proteoglycan Binding Skin Development Cell Differentiation Collagen Type I Trimer Collagen V Binding Cellular Developmental Process Collagen Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Kinase Regulator Activity Positive Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly Cell Surface Receptor Signaling Pathway Response To Wounding Vascular Endothelial Growth Factor Binding Basement Membrane Organization Blood Vessel Morphogenesis Cartilage Development Collagen Type XI Trimer Skeletal System Morphogenesis Cell Adhesion
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