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YAP1 and RUNX1
Number of citations of the paper that reports this interaction (PubMedID
10228168
)
85
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
YAP1
RUNX1
Description
Yes1 associated transcriptional regulator
RUNX family transcription factor 1
Image
GO Annotations
Cellular Component
Female Germ Cell Nucleus
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Membrane
Cell Junction
Anchoring Junction
TEAD-YAP Complex
Chromatin
Nucleus
Nucleoplasm
Core-binding Factor Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Proline-rich Region Binding
DNA-binding Transcription Factor Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Vasculogenesis
Blastocyst Development
Trophectodermal Cell Differentiation
Tissue Homeostasis
Glandular Epithelial Cell Differentiation
Heart Process
Embryonic Heart Tube Morphogenesis
DNA Damage Response
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Positive Regulation Of Cell Growth
Epithelial Cell Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Polarized Epithelial Cell Differentiation
Notochord Development
Response To Progesterone
Somatic Stem Cell Population Maintenance
Organ Growth
Hippo Signaling
Wound Healing
Regulation Of Cell Population Proliferation
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Paraxial Mesoderm Development
Lateral Mesoderm Development
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Bud Elongation Involved In Lung Branching
Lung Epithelial Cell Differentiation
Intestinal Epithelial Cell Differentiation
Intestinal Epithelial Cell Development
Regulation Of Canonical Wnt Signaling Pathway
Cardiac Muscle Tissue Regeneration
Canonical Glycolysis
Protein-containing Complex Assembly
Interleukin-6-mediated Signaling Pathway
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Regulation Of Stem Cell Proliferation
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cilium Assembly
Positive Regulation Of Stem Cell Population Maintenance
Enterocyte Differentiation
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Ossification
Chondrocyte Differentiation
Myeloid Leukocyte Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of Plasminogen Activation
Hemopoiesis
Myeloid Cell Differentiation
Neuron Differentiation
Negative Regulation Of Granulocyte Differentiation
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Collagen Biosynthetic Process
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Peripheral Nervous System Neuron Development
Positive Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Tissue Regeneration
Hematopoietic Stem Cell Proliferation
Positive Regulation Of Extracellular Matrix Organization
Regulation Of Connective Tissue Replacement
Regulation Of Multicellular Organismal Development
Pathways
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Formation of axial mesoderm
Zygotic genome activation (ZGA)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Developmental Lineage of Pancreatic Ductal Cells
Pre-NOTCH Transcription and Translation
SLC-mediated transport of organic cations
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
Regulation of RUNX1 Expression and Activity
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
RUNX1 regulates transcription of genes involved in WNT signaling
RUNX2 regulates genes involved in differentiation of myeloid cells
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
SARS-CoV-1 activates/modulates innate immune responses
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Acute myeloid leukemia (AML)
Chronic myeloid leukemia (CML)
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS
Cleft palate (
27018472
)
Colorectal cancer or advanced adenoma (
30510241
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Heel bone mineral density (
30598549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Migraine (
27322543
)
Offspring birth weight (
31043758
)
Polycystic ovary syndrome (
22885925
26416764
30566500
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Pulse pressure (
30224653
30578418
)
Reticulocyte count (
32888494
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Age-related cognitive decline (language) (slope of z-scores) (
30954325
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Appendicular lean mass (
33097823
)
Asthma (
34103634
32296059
31959851
31619474
31361310
30929738
)
Asthma (adult onset) (
31036433
30929738
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Brain-derived neurotrophic factor levels (
33345186
)
Breast cancer (
31757997
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Esophageal cancer (
21642993
)
Esophageal squamous cell carcinoma (
25129146
)
Femoral neck length (
30888730
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Gut microbiota alpha diversity (Chao1 index) (
33208821
)
HDL cholesterol (
30275531
)
Heel bone mineral density (
30598549
)
Height (
28552196
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Hip index (
34021172
)
IgG N-glycosylation phenotypes (multivariate analysis) (
32128391
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Male-pattern baldness (
28196072
29146897
27182965
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) (
21829377
)
Platelet count (
27863252
32888494
)
Plateletcrit (
32888494
27863252
)
Preeclampsia (
23551011
)
Psoriasis (
25903422
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Stroke (
32693751
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
103 interacting genes:
ABL1
AKT1
AMOT
ANK3
APC2
ARID2
ATN1
BEAN1
CCDC87
CDIP1
CNKSR2
CRTC3
CSNK1D
CSNK1E
DDN
EIF3H
ENAH
ENTREP3
ERBB4
ESS2
FBXW7
FOXI1
FOXJ3
FXR1
GAB1
GAS5
GBF1
GLIS3
HNRNPU
HNRNPUL1
IGSF9B
JCAD
JOSD2
KIF5A
LATS2
LINC00839
MAP2
MAP3K2
MAP3K3
MAPKAPK5
MLANA
MRPL49
MYCT1
NDFIP2
NEK1
NFE2
NHERF1
NR1I2
OTUB1
OTUD1
PIP4P1
PIP4P2
PKNOX2
PRR7
PRRG2
PRRG4
PTCH1
PTEN
PTPN21
RBM14
RHBDD2
RNF11
RNF38
RUNX1
RUNX2
RUNX3
SCAMP3
SCAMP4
SCN1A
SDCBP
SH3D21
SHISA4
SMAD1
SMAD7
SUMO3
TEAD1
TEAD2
TEAD3
TEAD4
TGFB1I1
TMEM139
TMEM151B
TMEM252
TMEM59L
TMEM61
TMEM92
TNRC18
TP53BP2
TP63
TP73
TRERF1
TRIP6
TSPYL2
TTYH3
UBE2L6
UCHL3
UVRAG
WBP1
WBP2
WT1
YWHAG
YWHAQ
YWHAZ
119 interacting genes:
ABCA2
ABHD14A
AGTPBP1
ALKBH6
APEH
AR
ARGLU1
ARID5B
ATP13A1
B4GAT1
BAG3
BAG4
BTBD2
CBFA2T2
CBFA2T3
CBFB
CCND1
CCND2
CCND3
CCNK
CDK1
CDK2
CDK6
CEBPA
CEBPB
CERCAM
CLIP4
CNOT3
CNRIP1
COPA
COPRS
DAZAP2
DNMT1
DTX2
DZIP3
EEF2
ELF1
ELF2
ELF4
EP300
FAM222B
FBXO17
FOS
FOXP3
FOXRED1
GCC1
GDI1
GSK3A
GTPBP6
HGS
HIPK1
HIPK2
HLA-DRB1
IDS
IKZF1
IKZF3
JUN
KAT6A
KAT6B
MAGI3
MAPK1
ME3
METTL26
MPPED2
MSTO1
MYOD1
NCOR1
NCOR2
NDST1
NFKBID
OLFM1
OLIG3
PAX5
PICK1
PKD1
PLEKHB1
PLEKHB2
PPP3CB
PRDM4
PRMT1
PRRC2A
PSMB4
RBFOX3
RBM14
RNF38
RNF44
SEC31B
SNRNP70
SNRPC
SPEN
SPI1
STUB1
SULT4A1
SUV39H1
TAFAZZIN
TCERG1
TEAD2
TEAD4
TEKT5
TLE1
TLE2
TLE5
TMEM222
TOLLIP
TRIM5
TUBA1B
UBE2L6
UHRF2
UROD
USP10
UXT
VDR
VPS37C
VPS39
WBP2
WWP1
WWTR1
YAP1
ZMYM4
Entrez ID
10413
861
HPRD ID
09424
01043
Ensembl ID
ENSG00000137693
ENSG00000159216
Uniprot IDs
K0KVU2
P46937
Q01196
PDB IDs
1JMQ
1K5R
1K9Q
1K9R
2LAW
2LAX
2LAY
2LTV
2LTW
3KYS
3MHR
4RE1
4REX
5OAQ
5YDX
5YDY
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GE3
6GE4
6GE5
6GE6
6GEC
6GEE
6GEG
6GEI
6GEK
6HIK
6HIL
6Q2X
7O07
8A8Q
8A8R
8C2F
8WRG
9FZA
1CMO
1CO1
1E50
1H9D
1LJM
Enriched GO Terms of Interacting Partners
?
WW Domain Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Hippo Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Organ Growth
Transcription Regulator Complex
Regulation Of RNA Metabolic Process
Regulation Of Developmental Growth
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Developmental Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Primary Metabolic Process
Sequence-specific Double-stranded DNA Binding
Regulation Of Ubiquitin-dependent Protein Catabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Cell Fate Commitment
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Growth
Regulation Of Cell Cycle
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Chromatin
Positive Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Gene Expression
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity
Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Cell Communication
Protein Phosphorylation
Regulation Of Mitotic Cell Cycle
Embryonic Organ Development
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Protein Domain Specific Binding
Golgi Localization
Nucleoplasm
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Transcription Corepressor Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Nucleus
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Macromolecule Metabolic Process
Cell Differentiation
DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Transcription Regulator Complex
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Transcription Coactivator Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
Cellular Developmental Process
Regulation Of Cell Differentiation
Chromatin Binding
Developmental Process
Leukocyte Differentiation
Mononuclear Cell Differentiation
Chromatin
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Chromatin Remodeling
Cyclin-dependent Protein Serine/threonine Kinase Activity
Transcription By RNA Polymerase II
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Tagcloud (Intersection)
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