YAP1 and RUNX1

Number of citations of the paper that reports this interaction (PMID 10228168)
96

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		YAP1	RUNX1
Gene Name		Yes-associated protein 1	runt-related transcription factor 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Membrane Cell Junction	Basement Membrane Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Regulatory Region DNA Binding Proline-rich Region Binding	Regulatory Region DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Repressing Transcription Factor Binding
	Biological Process	Cell Morphogenesis Vasculogenesis Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Cell Proliferation Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Somatic Stem Cell Maintenance Hippo Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Contact Inhibition Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Skeletal System Development In Utero Embryonic Development Liver Development Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Central Nervous System Development Regulation Of Signal Transduction Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Hair Follicle Morphogenesis Embryonic Hemopoiesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Response To Pain Peripheral Nervous System Neuron Development Definitive Hemopoiesis Regulation Of Hair Follicle Cell Proliferation Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Progesterone Secretion
Pathways		PPARA activates gene expression Nuclear signaling by ERBB4 Fatty acid, triacylglycerol, and ketone body metabolism Signaling by Hippo Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by ERBB4
Drugs
Diseases
GWAS		MRI atrophy measures ( 21116278) Polycystic ovary syndrome ( 22885925) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627)	Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22542470) Phospholipid levels (plasma) ( 21829377) Preeclampsia ( 23551011)
Protein-Protein Interactions		28 interactors: ABL1 AKT1 BTRC DENND3 ERBB4 HNRNPU KIF5A LATS1 LATS2 NFE2 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP63 TP73 WBP1 WBP2 YWHAG YWHAQ	46 interactors: AES AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COPRS CTBP2 DNMT1 EFNA2 ELF2 ELF4 EP300 ETS1 FOS FOXP3 HDAC1 HDAC3 HIPK1 HIPK2 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 PAX5 PRMT1 RBM14 SPEN STUB1 SUV39H1 TAZ TLE1 TLE2 UBE2L6 UXT VDR WWTR1 YAP1
Entrez ID		10413	861
HPRD ID		09424	01043
Ensembl ID		ENSG00000137693	ENSG00000159216
Uniprot IDs		K0KVU2 P46937 Q86T74	Q01196
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR	1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?		Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Organ Development Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Developmental Process Anatomical Structure Development Epithelium Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Regulation Of Metabolic Process Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Phosphorylation Signaling Tissue Development Cell Communication Positive Regulation Of Cell Differentiation Embryo Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Cell Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Gene Expression Response To Organic Substance DNA-templated Transcription, Initiation	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Developmental Process System Development Regulation Of Cellular Process Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Notch Signaling Pathway Chromatin Organization Cellular Metabolic Process Chromatin Modification Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cell Differentiation Response To Organic Substance
Tagcloud ?		alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated
Tagcloud (Difference) ?		alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated
Tagcloud (Intersection) ?