YAP1 and TSPYL2

Number of citations: 104 (PubMedID 35044719)
Data Source: BioGRID (unspecified method)

		YAP1	TSPYL2
Name		Yes1 associated transcriptional regulator	TSPY like 2
Structure			No pdb structure
GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction TEAD-YAP Complex	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding	RDNA Binding Chromatin Binding Protein Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Blastocyst Development Trophectodermal Cell Differentiation Tissue Homeostasis Glandular Epithelial Cell Differentiation Heart Process Embryonic Heart Tube Morphogenesis DNA Damage Response Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Cell Growth Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Notochord Development Response To Progesterone Somatic Stem Cell Population Maintenance Organ Growth Hippo Signaling Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Intestinal Epithelial Cell Development Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Tissue Regeneration Canonical Glycolysis Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Positive Regulation Of Stem Cell Population Maintenance Enterocyte Differentiation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chromatin Organization Nucleosome Assembly Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways		Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of axial mesoderm Zygotic genome activation (ZGA) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription Developmental Lineage of Pancreatic Ductal Cells	XBP1(S) activates chaperone genes
GWAS		Cleft palate ( 27018472 ) Colorectal cancer or advanced adenoma ( 30510241 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Migraine ( 27322543 ) Offspring birth weight ( 31043758 ) Polycystic ovary syndrome ( 22885925 26416764 30566500 ) Prostate cancer ( 23535732 ) Pubertal anthropometrics ( 23449627 ) Pulse pressure ( 30224653 30578418 ) Reticulocyte count ( 32888494 ) Whole-brain volume (Alzheimer's disease interaction) ( 21116278 )	No GWAS studies recorded
Interacting Genes		103 interacting genes: ABL1 AKT1 AMOT ANK3 APC2 ARID2 ATN1 BEAN1 CCDC87 CDIP1 CNKSR2 CRTC3 CSNK1D CSNK1E DDN EIF3H ENAH ENTREP3 ERBB4 ESS2 FBXW7 FOXI1 FOXJ3 FXR1 GAB1 GAS5 GBF1 GLIS3 HNRNPU HNRNPUL1 IGSF9B JCAD JOSD2 KIF5A LATS2 LINC00839 MAP2 MAP3K2 MAP3K3 MAPKAPK5 MLANA MRPL49 MYCT1 NDFIP2 NEK1 NFE2 NHERF1 NR1I2 OTUB1 OTUD1 PIP4P1 PIP4P2 PKNOX2 PRR7 PRRG2 PRRG4 PTCH1 PTEN PTPN21 RBM14 RHBDD2 RNF11 RNF38 RUNX1 RUNX2 RUNX3 SCAMP3 SCAMP4 SCN1A SDCBP SH3D21 SHISA4 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TGFB1I1 TMEM139 TMEM151B TMEM252 TMEM59L TMEM61 TMEM92 TNRC18 TP53BP2 TP63 TP73 TRERF1 TRIP6 TSPYL2 TTYH3 UBE2L6 UCHL3 UVRAG WBP1 WBP2 WT1 YWHAG YWHAQ YWHAZ	51 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 DYRK1A EEF1A1 EZH2 GFI1B H2BC15 H3C1 HMGXB4 INO80B KDM6A KDM6B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B YAP1 ZBTB24 ZBTB48 ZFP1 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835
Entrez ID		10413	64061
HPRD ID		09424	06713
Ensembl ID		ENSG00000137693	ENSG00000184205
Uniprot IDs		K0KVU2 P46937	Q9H2G4
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X 7O07 8A8Q 8A8R 8C2F 8WRG 9FZA	Not available
GO Terms Enriched among Interactors		WW Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Organ Growth Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of Developmental Growth Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Regulation Of Growth Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Gene Expression Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Communication Protein Phosphorylation Regulation Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Protein Domain Specific Binding Golgi Localization	Nucleus Chromatin Organization Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Nucleolus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Repair RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA Metabolic Process Chromatin Binding Zinc Ion Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin DNA Binding Transcription Regulator Complex Cyclin B1-CDK1 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Metal Ion Binding Cellular Response To Stress Telomere Organization Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3K27me2/H3K27me3 Demethylase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA Repair Protein Localization To Site Of Double-strand Break Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cardiac Muscle Cell Proliferation Cyclin-dependent Protein Serine/threonine Kinase Activity