YAP1 and GBF1

Number of citations: 104 (PubMedID 35044719)
Data Source: BioGRID (unspecified method)

		YAP1	GBF1
Name		Yes1 associated transcriptional regulator	golgi brefeldin A resistant guanine nucleotide exchange factor 1
Structure			No pdb structure
GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction TEAD-YAP Complex	Golgi Membrane Cytoplasm Peroxisome Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Stack Cis-Golgi Network Trans-Golgi Network Lipid Droplet Cytosol Membrane Cell Leading Edge Golgi Apparatus Subcompartment
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Blastocyst Development Trophectodermal Cell Differentiation Tissue Homeostasis Glandular Epithelial Cell Differentiation Heart Process Embryonic Heart Tube Morphogenesis DNA Damage Response Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Cell Growth Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Notochord Development Response To Progesterone Somatic Stem Cell Population Maintenance Organ Growth Hippo Signaling Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Intestinal Epithelial Cell Development Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Tissue Regeneration Canonical Glycolysis Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Positive Regulation Of Stem Cell Population Maintenance Enterocyte Differentiation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Activation Involved In Immune Response Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Golgi Organization Regulation Of Mitotic Cell Cycle Endomembrane System Organization Protein Transport Endosomal Transport Neutrophil Chemotaxis Regulation Of ARF Protein Signal Transduction Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi COPI Coating Of Golgi Vesicle Cilium Assembly Establishment Of Monopolar Cell Polarity Protein Localization To Endoplasmic Reticulum Exit Site Golgi Disassembly Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Cellular Response To Virus Reactive Oxygen Species Biosynthetic Process Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Protein Localization To Cell Surface
Pathways		Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of axial mesoderm Zygotic genome activation (ZGA) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription Developmental Lineage of Pancreatic Ductal Cells	trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
GWAS		Cleft palate ( 27018472 ) Colorectal cancer or advanced adenoma ( 30510241 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Migraine ( 27322543 ) Offspring birth weight ( 31043758 ) Polycystic ovary syndrome ( 22885925 26416764 30566500 ) Prostate cancer ( 23535732 ) Pubertal anthropometrics ( 23449627 ) Pulse pressure ( 30224653 30578418 ) Reticulocyte count ( 32888494 ) Whole-brain volume (Alzheimer's disease interaction) ( 21116278 )	Adult body size ( 32376654 ) General cognitive ability ( 29844566 ) Hand grip strength ( 29313844 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) QT interval ( 24952745 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Triglyceride levels ( 32154731 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		103 interacting genes: ABL1 AKT1 AMOT ANK3 APC2 ARID2 ATN1 BEAN1 CCDC87 CDIP1 CNKSR2 CRTC3 CSNK1D CSNK1E DDN EIF3H ENAH ENTREP3 ERBB4 ESS2 FBXW7 FOXI1 FOXJ3 FXR1 GAB1 GAS5 GBF1 GLIS3 HNRNPU HNRNPUL1 IGSF9B JCAD JOSD2 KIF5A LATS2 LINC00839 MAP2 MAP3K2 MAP3K3 MAPKAPK5 MLANA MRPL49 MYCT1 NDFIP2 NEK1 NFE2 NHERF1 NR1I2 OTUB1 OTUD1 PIP4P1 PIP4P2 PKNOX2 PRR7 PRRG2 PRRG4 PTCH1 PTEN PTPN21 RBM14 RHBDD2 RNF11 RNF38 RUNX1 RUNX2 RUNX3 SCAMP3 SCAMP4 SCN1A SDCBP SH3D21 SHISA4 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TGFB1I1 TMEM139 TMEM151B TMEM252 TMEM59L TMEM61 TMEM92 TNRC18 TP53BP2 TP63 TP73 TRERF1 TRIP6 TSPYL2 TTYH3 UBE2L6 UCHL3 UVRAG WBP1 WBP2 WT1 YWHAG YWHAQ YWHAZ	9 interacting genes: CDK1 PNPLA2 SRPK2 UBC USO1 WEE2-AS1 YAP1 YWHAG ZYG11B
Entrez ID		10413	8729
HPRD ID		09424	04740
Ensembl ID		ENSG00000137693	ENSG00000107862
Uniprot IDs		K0KVU2 P46937	A0A669KB10 A0A669KBG8 A0A7I2V2L5 A0A7I2V452 A0A7I2V514 A0A7I2YQ65 Q92538
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X 7O07 8A8Q 8A8R 8C2F 8WRG 9FZA	Not available
GO Terms Enriched among Interactors		WW Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Organ Growth Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of Developmental Growth Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Regulation Of Growth Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Gene Expression Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Communication Protein Phosphorylation Regulation Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Protein Domain Specific Binding Golgi Localization	Organelle Fusion Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Positive Regulation Of Organ Growth Regulation Of Heart Growth Golgi Vesicle Docking Enterocyte Differentiation Organelle Disassembly Nucleus Organization Intracellular Signal Transduction Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin B1-CDK1 Complex Regulation Of Organ Growth Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Cyclin-dependent Protein Kinase Activity Protein Kinase C Inhibitor Activity TEAD-YAP Complex Negative Regulation Of Triglyceride Storage Mono-olein Transacylation Activity Diolein Transacylation Activity Acylglycerol Acyl-chain Remodeling Golgi Organization Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Nuclear Speck Organization Lateral Mesoderm Development Cardiac Muscle Tissue Regeneration Acylglycerol O-acyltransferase Activity Pre-mRNA 5'-splice Site Binding