HMG20B and BRCA2

Number of citations of the paper that reports this interaction (PMID 11207365)
25

Data Source:
HPRD (in vivo, in vitro)

		HMG20B	BRCA2
Gene Name		high mobility group 20B	breast cancer 2, early onset
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Blood Coagulation Negative Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production	Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		15 interactors: APP BRCA2 CCDC102B CCDC136 CCDC85B HNRNPL KIF4A KRT15 KRT38 NKX3-1 PHF21A SYCE1 TACC2 TFIP11 VIM	34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11
Entrez ID		10362	675
HPRD ID		05703	02554
Ensembl ID		ENSG00000064961	ENSG00000139618
Uniprot IDs		Q9P0W2	P51587
PDB IDs			1N0W 3EU7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Cell Cycle Suckling Behavior Cell Cycle Process Developmental Process Axon Cargo Transport Cell Cycle Positive Regulation Of Cell Cycle Microtubule-based Process Spliceosomal Complex Disassembly Anatomical Structure Development Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Apoptotic Process Feeding Behavior Central Nervous System Development MRNA Processing Blood Coagulation Cell Division Hemostasis Programmed Cell Death Microtubule Cytoskeleton Organization Meiosis I Cytokinesis Cell Death Death Collateral Sprouting In Absence Of Injury Negative Regulation Of Estrogen Receptor Binding System Development Cytoskeleton Organization Organ Development Spindle Organization Negative Regulation Of Epithelial Cell Proliferation Microtubule-based Transport MRNA Metabolic Process Cytoskeleton-dependent Intracellular Transport Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Binding Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Peptidase Activity Cell Maturation RNA Processing RNA Metabolic Process Regulation Of Body Fluid Levels Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Wound Healing Nucleobase-containing Compound Metabolic Process	Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process
Tagcloud ?			185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1
Tagcloud (Difference) ?			185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1
Tagcloud (Intersection) ?