HMG20B and WAC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMG20B	WAC
Description		high mobility group 20B	WW domain containing adaptor with coiled-coil
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Body	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	Chromatin Organization Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation	Chromatin Organization Chromatin Remodeling DNA Damage Response Regulation Of Autophagy Positive Regulation Of Macroautophagy Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of TORC1 Signaling
Pathways		HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma ( 27363682)
Interacting Genes		27 interacting genes: APP BRCA2 C14orf119 CCDC102B CCDC136 CCDC85B E2F6 ERP29 FBXO7 HNRNPL KIF4A KRT15 KRT38 MID1 NKX3-1 NUTF2 PHF21A PIAS2 PPP1R13B SNAPC5 SYCE1 TACC2 TFIP11 TRAF1 USHBP1 VIM WAC	29 interacting genes: AKAP9 APP BACH1 CCDC6 CDC37 CDK1 CRKL DYDC1 HMG20B KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 PLK1 SYTL5 TFIP11 TNS2 TRAF1 TRAF3IP1 TRAF3IP3 TTC3 UBC UBQLN4 VCP VCPIP1 ZDHHC17
Entrez ID		10362	51322
HPRD ID		05703	18291
Ensembl ID		ENSG00000064961	ENSG00000095787
Uniprot IDs		Q9P0W2	Q9BTA9
PDB IDs
Enriched GO Terms of Interacting Partners?			Cytoplasm Post-translational Protein Modification Protein Modification By Small Protein Conjugation Response To Copper Ion Microtubule-based Process Identical Protein Binding Protein Modification Process Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Protein Ubiquitination Microtubule Binding Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Mitotic Nuclear Membrane Disassembly DNA Metabolic Process DNA Repair Centrosome Separation Transport Along Microtubule Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nuclear Membrane Disassembly Cytoskeleton-dependent Intracellular Transport Membrane Disassembly Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Microtubule-based Transport Cellular Response To Copper Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Microtubule Cytoskeleton Organization Protein Localization To Site Of Double-strand Break Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Cytoskeleton Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium
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