AKR1A1 and HTR6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		AKR1A1	HTR6
Description		aldo-keto reductase family 1 member A1	5-hydroxytryptamine receptor 6
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Synapse Extracellular Exosome	Plasma Membrane Cilium Membrane Dendrite Synapse
	Molecular Function	Aldose Reductase (NADPH) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity Glycerol Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADH) Activity S-nitrosoglutathione Reductase (NADPH) Activity Methylglyoxal Reductase (NADPH) (acetol Producing) Activity	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Lipid Metabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate D-glucuronate Catabolic Process Negative Regulation Of Apoptotic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Glutathione conjugation Formation of xylulose-5-phosphate	Serotonin receptors G alpha (s) signalling events
Drugs		Tolrestat Nicotinamide adenine dinucleotide phosphate Copper	Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 27863252 32888494) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		5 interacting genes: EXOSC4 FOXP1 HTR6 TERF1 TERF2IP	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		10327	3362
HPRD ID		00069	03066
Ensembl ID		ENSG00000117448	ENSG00000158748
Uniprot IDs		P14550 V9HWI0	P50406
PDB IDs		2ALR	7XTB 7YS6 8JLZ
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Organization Positive Regulation Of Interleukin-21 Production Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Chromosome, Telomeric Region Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Histamine Receptor Activity Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Regulation Of Chromosome Organization Ankyrin Repeat Binding Osteoclast Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Protection From Non-homologous End Joining At Telomere Exoribonuclease Complex Meiotic Telomere Clustering Negative Regulation Of Macromolecule Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of B Cell Receptor Signaling Pathway Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Positive Regulation Of DNA Metabolic Process Telomere Localization Telomeric D-loop Disassembly	Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH
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