SPRY1 and FBLN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPRY1	FBLN1
Description		sprouty RTK signaling antagonist 1	fibulin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Protein Binding	Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation
Pathways		EGFR downregulation	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		87 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 FXR1 FXR2 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837	66 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CRIPTO CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 FXR1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KLHL20 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 NUFIP2 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TRIM42 UNKL VCAN YWHAQ
Entrez ID		10252	2192
HPRD ID		06782	00629
Ensembl ID		ENSG00000164056	ENSG00000077942
Uniprot IDs		O43609	A0A8S0LWY1 P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratin Filament Intermediate Filament Keratinization Tissue Development Identical Protein Binding Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission	Extracellular Matrix Tissue Development Epidermis Development Keratinization Extracellular Matrix Structural Constituent Developmental Process Integrin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Signal Transduction Response To Interleukin-1 Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Angiogenesis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of System Process Anatomical Structure Formation Involved In Morphogenesis Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Development Calcium-independent Cell-matrix Adhesion Embryonic Pattern Specification Adrenal Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding Extracellular Region Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Collagen Binding Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of MiRNA Transcription Cell Migration Regulation Of Spontaneous Synaptic Transmission Activin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process
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