SPRY1 and LCE2D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPRY1	LCE2D
Gene Name		sprouty homolog 1, antagonist of FGF signaling (Drosophila)	late cornified envelope 2D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane
	Molecular Function	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade	Keratinization
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NL OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1	14 interactors: ADAMTSL4 EFEMP2 GLRX3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 NOTCH2NL OTX1 PLSCR1 RGS20 SPRY1 SPRY2 SUMO1P1
Entrez ID		10252	353141
HPRD ID		06782	17261
Ensembl ID		ENSG00000164056	ENSG00000187223
Uniprot IDs		O43609	Q5TA82
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development System Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of ERBB Signaling Pathway Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Pattern Specification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Pons Development Anterior/posterior Pattern Specification Inner Ear Morphogenesis Sensory Organ Development Regulation Of Phosphorus Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Embryonic Morphogenesis Ear Morphogenesis Negative Regulation Of Signal Transduction Metencephalon Development Embryo Development Transcription, DNA-templated Negative Regulation Of Signaling Negative Regulation Of Phosphorylation RNA Biosynthetic Process Hindbrain Development RNA Metabolic Process Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Inner Ear Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Keratinization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Branch Elongation Of An Epithelium Negative Regulation Of GTPase Activity Axis Elongation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Spindle Localization Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Lung Morphogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of MAP Kinase Activity Inner Ear Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Establishment Of Cell Polarity Ear Morphogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Phosphatidylserine Biosynthetic Process Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Diencephalon Morphogenesis Branching Morphogenesis Of An Epithelial Tube Regulation Of GTPase Activity Negative Regulation Of Protein Kinase Activity Lung Growth Negative Regulation Of Kinase Activity Ear Development Morphogenesis Of A Branching Epithelium Lung Development Morphogenesis Of A Branching Structure Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?