USPL1 and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (enzymatic study, two hybrid, two hybrid)

		USPL1	SUMO3
Description		ubiquitin specific peptidase like 1	small ubiquitin like modifier 3
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cajal Body	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO Binding Ubiquitin Binding	Protein Binding Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Proteolysis Cell Population Proliferation SnRNA Transcription Protein Desumoylation Cajal Body Organization	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways			SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Delirium ( 29631748)
Interacting Genes		6 interacting genes: RANGAP1 SP100 SUMO1 SUMO2 SUMO3 TSC2	62 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A COPS5 CUL3 DAXX EGLN3 FAM221A FOS HIPK1 HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PAX6 PCGF2 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAD54L2 RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SNRNP70 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZMYM2 ZNF451 ZNF496
Entrez ID		10208	6612
HPRD ID		09833	03754
Ensembl ID		ENSG00000132952	ENSG00000184900
Uniprot IDs		A8K1B1 B3KQ64 Q5W0Q7	P55854
PDB IDs		7P99 7ZJU 7ZJV	1U4A 2IO1 2MP2 6K5R 6NNQ 7R2E 7ZJU
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Tag Activity PML Body Ubiquitin-like Protein Ligase Binding Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Intracellular Transport Negative Regulation Of Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Negative Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Localization Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Regulation Of Intracellular Transport Post-translational Protein Modification Maintenance Of Protein Localization In Organelle Ubiquitin Protein Ligase Binding Regulation Of Protein Localization Regulation Of DNA Binding Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Negative Regulation Of Transport Regulation Of Protein Transport Maintenance Of Location Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Pore Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Cytoplasmic Periphery Of The Nuclear Pore Complex Protein Metabolic Process Regulation Of Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Modification Process TSC1-TSC2 Complex Protein Localization To Nuclear Pore Regulation Of Protein Localization To Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Kinetochore	PML Body Protein Sumoylation Nucleus Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process SUMO Binding SMAD Protein Signal Transduction Cellular Response To Stress SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Postsynaptic Cytosol Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process DeSUMOylase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Protein Sumoylation Protein Desumoylation Transcription Coregulator Activity Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Presynaptic Cytosol
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