USPL1 and SUMO3

Number of citations of the paper that reports this interaction (PMID 22878415)
10

Data Source:
BioGRID (enzymatic study, two hybrid)

		USPL1	SUMO3
Gene Name		ubiquitin specific peptidase like 1	small ubiquitin-like modifier 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cajal Body	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding SUMO Binding Ubiquitin Binding SUMO-specific Isopeptidase Activity	Protein Binding SUMO Transferase Activity
	Biological Process	Proteolysis Cell Proliferation Protein Desumoylation Cajal Body Organization	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: RANGAP1 SP100 SUMO1 SUMO2 SUMO3	53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM
Entrez ID		10208	6612
HPRD ID		09833	03754
Ensembl ID		ENSG00000132952	ENSG00000184900
Uniprot IDs		A8K1B1 Q5W0Q7	B4DUW4 P55854
PDB IDs			1U4A 2IO1
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Peptidyl-lysine Modification Regulation Of Protein Export From Nucleus Positive Regulation Of Proteolysis Negative Regulation Of DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Binding Negative Regulation Of Intracellular Protein Transport Protein Modification By Small Protein Conjugation Negative Regulation Of Binding Regulation Of Proteolysis Negative Regulation Of Intracellular Transport Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Interferon-gamma Regulation Of Fas Signaling Pathway Response To Interferon-gamma Protein Localization To Nucleus Negative Regulation Of Protein Transport Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport PML Body Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Binding Protein Localization To Nuclear Pore Positive Regulation Of Ran GTPase Activity Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Metabolic Process Protein Localization To Nuclear Envelope Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transport DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Metabolic Process Regulation Of Intracellular Transport Cytokine-mediated Signaling Pathway Protein Localization To Organelle Regulation Of Interferon-gamma-mediated Signaling Pathway	Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?			aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Difference) ?			aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Intersection) ?