USPL1 and SP100

Number of citations of the paper that reports this interaction (PubMedID 22878415)
26

Data Source:
BioGRID (enzymatic study)

		USPL1	SP100
Description		ubiquitin specific peptidase like 1	SP100 nuclear antigen
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cajal Body	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body PML Body Mre11 Complex Nuclear Periphery
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO Binding Ubiquitin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Protein Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromo Shadow Domain Binding
	Biological Process	Proteolysis Cell Population Proliferation SnRNA Transcription Protein Desumoylation Cajal Body Organization	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Negative Regulation Of Endothelial Cell Migration DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Type II Interferon Maintenance Of Protein Location Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Regulation Of Viral Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins Interferon gamma signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		6 interacting genes: RANGAP1 SP100 SUMO1 SUMO2 SUMO3 TSC2	39 interacting genes: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREBBP CREM DNMT3A DYRK2 ETS1 GIPC2 HEMGN HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML POLR3C RANBP2 RBM39 RTP5 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBE2I USPL1 ZC2HC1A
Entrez ID		10208	6672
HPRD ID		09833	06844
Ensembl ID		ENSG00000132952	ENSG00000067066
Uniprot IDs		A8K1B1 B3KQ64 Q5W0Q7	P23497
PDB IDs		7P99 7ZJU 7ZJV	1H5P 4PTB 5FB0 5FB1 5PWE 5PWF 5PWG 5PWH 5PWI 5PWJ 5PWK 5PWL 5PWM 5PWN 5PWO 5PWP 5PWQ 5PWR 5PWS 5PWT 5PWU 5PWV 5PWW 5PWX 5PWY 5PWZ 5PX0 5PX1 5PX2 5PX3 5PX4 5PX5 5PX6 5PX7 5PX8 5PX9 5PXA 5PXB 5PXC 5PXD 5PXE 5PXF 5PXG 5PXH 5PXI 5PXJ 5PXK 5PXL 5PXM 5PXN 5PXO 5PXP 5PXQ 5PXR 5PXS 5PXT 5PXU 5PXV 5PXW 5PXX 5PXY 5PXZ 5PY0 5PY1 5PY2 5PY3 5PY4 5PY5 5PY6 5PY7 5PY8 5PY9 5PYA 5PYB 5PYC 5PYD 5PYE 5PYF 5PYG 5PYH 5PYI 5PYJ 5PYK 5PYL 5PYM 5PYN 5PYO 5PYP 5PYQ 5PYR 5PYS 5PYT 5PYU 5PYV 5PYW 5PYX 5PYY 5PYZ 5PZ0 5PZ1 5PZ2 5PZ3 5PZ4 5PZ5 5PZ6 5PZ7 5PZ8 5PZ9 5PZA 5PZB 5PZC 5PZD 5PZE 5PZF 5PZG 5PZH 5PZI 5PZJ 6G5N 6G5P
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Tag Activity PML Body Ubiquitin-like Protein Ligase Binding Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Intracellular Transport Negative Regulation Of Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Negative Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Localization Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Regulation Of Intracellular Transport Post-translational Protein Modification Maintenance Of Protein Localization In Organelle Ubiquitin Protein Ligase Binding Regulation Of Protein Localization Regulation Of DNA Binding Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Negative Regulation Of Transport Regulation Of Protein Transport Maintenance Of Location Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Pore Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Cytoplasmic Periphery Of The Nuclear Pore Complex Protein Metabolic Process Regulation Of Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Modification Process TSC1-TSC2 Complex Protein Localization To Nuclear Pore Regulation Of Protein Localization To Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Kinetochore	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Nucleoplasm PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Body Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process PML Body Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Nucleus Nuclear Body SUMO Transferase Activity Chromosome, Telomeric Region Shelterin Complex Presynaptic Cytosol Postsynaptic Cytosol DNA Damage Response Nuclear Telomere Cap Complex Chromatin Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Nucleus Organization Telomere Capping Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Heterochromatin Negative Regulation Of Transcription By RNA Polymerase II Post-translational Protein Modification Chromatin Remodeling Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process
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