GDF11 and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 16845371)
20

Data Source:
HPRD (in vitro, in vivo)

		GDF11	ACVR2B
Description		growth differentiation factor 11	activin A receptor type 2B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Skeletal System Development Metanephros Development Ureteric Bud Development Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Mesoderm Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Spinal Cord Anterior/posterior Patterning Neuron Differentiation Pancreas Development Activin Receptor Signaling Pathway Amacrine Cell Differentiation Negative Regulation Of Neuron Differentiation Camera-type Eye Morphogenesis Roof Of Mouth Development Positive Regulation Of SMAD Protein Signal Transduction Type B Pancreatic Cell Maturation Negative Regulation Of Amacrine Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development
Pathways			Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Refractive error ( 32231278)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)
Interacting Genes		1 interacting genes: ACVR2B	26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		10220	93
HPRD ID		04895	04106
Ensembl ID		ENSG00000135414	ENSG00000114739
Uniprot IDs		O95390	Q13705
PDB IDs		5E4G 5JHW 5UHM 6MAC 7MRZ	2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Venous Blood Vessel Development Activin Receptor Complex Activin Receptor Activity, Type II Activin Receptor Activity Trophoblast Cell Migration Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Embryonic Foregut Morphogenesis Activin Binding Negative Regulation Of Adipose Tissue Development Negative Regulation Of Mitophagy Kinase Activator Activity Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Gastrulation With Mouth Forming Second Regulation Of Adipose Tissue Development Endoplasmic Reticulum Tubular Network Pancreas Development Regulation Of Activin Receptor Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Endothelial Cell Differentiation Activin Receptor Signaling Pathway Growth Factor Binding Artery Development Insulin Secretion Gastrulation Negative Regulation Of Cold-induced Thermogenesis Organ Growth Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Blood Vessel Remodeling Negative Regulation Of Macroautophagy Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Multicellular Organismal Development Positive Regulation Of Ossification Mesoderm Development Vasculature Development Receptor Tyrosine Kinase Binding Peptide Hormone Secretion Positive Regulation Of Osteoblast Differentiation Post-embryonic Development Roof Of Mouth Development Regulation Of Bone Mineralization Intracellular Iron Ion Homeostasis Odontogenesis Of Dentin-containing Tooth	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation
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