GDF11 and ACVR2B

Number of citations of the paper that reports this interaction (PMID 16845371)
21

Data Source:
HPRD (in vivo, in vitro)

		GDF11	ACVR2B
Gene Name		growth differentiation factor 11	activin A receptor, type IIB
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding
	Biological Process	Skeletal System Development Metanephros Development Ureteric Bud Development Nervous System Development Mesoderm Development Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spinal Cord Anterior/posterior Patterning Pancreas Development Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Cell Development Cell Maturation Camera-type Eye Morphogenesis Palate Development SMAD Protein Signal Transduction	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye
Pathways			Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ACVR2B	18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		10220	93
HPRD ID		04895	04106
Ensembl ID		ENSG00000135414	ENSG00000114739
Uniprot IDs		O95390	Q13705
PDB IDs			2H62 2QLU 4FAO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Lymphangiogenesis Lymph Vessel Morphogenesis Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Embryonic Foregut Morphogenesis Foregut Morphogenesis Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Insulin Secretion Positive Regulation Of Biomineral Tissue Development Blood Vessel Remodeling Gastrulation With Mouth Forming Second Artery Development Peptide Hormone Secretion Peptide Secretion Digestive Tract Morphogenesis Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Endothelial Cell Differentiation Hormone Secretion Endothelium Development Hormone Transport Peptide Transport Pancreas Development Positive Regulation Of Ossification Organ Growth Odontogenesis Of Dentin-containing Tooth Palate Development Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Protein Secretion Regulation Of Osteoblast Differentiation Amide Transport Response To Glucose Odontogenesis Digestive Tract Development Post-embryonic Development Mesoderm Development Digestive System Development Retina Development In Camera-type Eye Response To Carbohydrate Gastrulation Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process
Tagcloud ?		ace activin actriib anemia cotreatment epo erythrocyte erythroid erythropoiesis erythropoietic erythropoietin ex hyperplasia iib implicate ineffective late maturation potently precursors progressively rap smad2 superfamily synergistic transforming trapping unlike version	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?		ace activin actriib anemia cotreatment epo erythrocyte erythroid erythropoiesis erythropoietic erythropoietin ex hyperplasia iib implicate ineffective late maturation potently precursors progressively rap smad2 superfamily synergistic transforming trapping unlike version	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?