PPIF and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPIF	ARFIP2
Description		peptidylprolyl isomerase F	ARF interacting protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Permeability Transition Pore Complex Mitochondrial Matrix Membrane	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Response To Ischemia Protein Folding Apoptotic Process Response To Oxidative Stress Mitochondrion Organization Apoptotic Mitochondrial Changes Regulation Of Proton-transporting ATPase Activity, Rotational Mechanism Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Mitochondrial Depolarization Muscle Structure Development Necroptotic Process Cellular Response To Hydrogen Peroxide Cellular Response To Arsenic-containing Substance Cellular Response To Calcium Ion Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Oxidative Phosphorylation Skeletal Muscle Fiber Differentiation Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site
Pathways			Retrograde transport at the Trans-Golgi-Network
Drugs		Cyclosporine Proline Triglyme Coumarin 120
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Height ( 20881960 31562340) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Triglyceride levels ( 32203549)	Malaria ( 31844061)
Interacting Genes		19 interacting genes: ABI2 AGTRAP ARFIP2 BANP CIDEB CMTM5 FAM25A FAM25C FAM25G FKBP7 MAGEA11 MUC1 PRB3 SERPINB5 SLC25A4 SYP SYPL1 VDAC1 YIF1A	61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1
Entrez ID		10105	23647
HPRD ID		06839	07209
Ensembl ID		ENSG00000108179	ENSG00000132254
Uniprot IDs		P30405	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		2BIT 2BIU 2Z6W 3QYU 3R49 3R4G 3R54 3R56 3R57 3R59 3RCF 3RCG 3RCI 3RCK 3RCL 3RD9 3RDA 3RDB 3RDC 4J58 4J59 4J5A 4J5B 4J5C 4J5D 4J5E 4O8H 4O8I 4XNC 4ZSC 4ZSD 5A0E 5CBT 5CBU 5CBV 5CBW 5CCN 5CCQ 5CCR 5CCS 6R8L 6R8O 6R8W 6R9S 6R9U 6R9X 6RA1 6Y3E 6YBM 7OGI 7PMT 7R2H 7R2I 7R2J 7R2L 7TGS 7TGT 7TGU 7TGV 7TH1 7TH6 7TH7 7THC 7THD 7THF 7ZDN 8EJX 8UC4 8UC5	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Mitochondrial Permeability Transition Pore Complex	Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process
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