ACTR3 and JUND

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		ACTR3	JUND
Description		actin related protein 3	JunD proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Site Of Double-strand Break Cell Projection Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-containing Complex Protein-DNA Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cell Projection Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Actin Polymerization-dependent Cell Motility Cellular Response To Type II Interferon	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Circadian Rhythm Response To Light Stimulus Response To Mechanical Stimulus Gene Expression Response To Lipopolysaccharide Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Cell Cycle Cellular Response To Calcium Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Forskolin
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Regulation of PD-L1(CD274) transcription
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 30604766 31015462) Hand grip strength ( 29691431) Systemic lupus erythematosus ( 33536424) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)
Interacting Genes		18 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN ERCC6 HCLS1 JUND LINC01554 OGT SHARPIN UBE3A WASF2 WASF3 WASL	30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 MIR9-2HG NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		10096	3727
HPRD ID		05024	01304
Ensembl ID		ENSG00000115091	ENSG00000130522
Uniprot IDs		B4DXW1 P61158	P17535
PDB IDs		6UHC 6YW6 6YW7 8P94	3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 7UCC 7UCD
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Actin Filament Organization Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Actin Nucleation Regulation Of Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Binding Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Actin Cytoskeleton Organization Glutamatergic Synapse Cytoskeleton Actin Filament Binding Structural Constituent Of Cytoskeleton Site Of Double-strand Break Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Protein Polymerization Positive Regulation Of Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Regulation Of Organelle Organization Positive Regulation Of Cell Projection Organization Cell Projection Assembly Cell Projection Regulation Of Plasma Membrane Bounded Cell Projection Organization Postsynapse Focal Adhesion	Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of Metabolic Process Intracellular Signal Transduction RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Nucleoplasm DNA Binding Cellular Response To Stress Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To Nutrient Levels Intracellular Signaling Cassette Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Negative Regulation Of Metabolic Process Response To Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Enzyme Binding R-SMAD Binding DNA-templated Transcription DNA Damage Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?