ACTR3 and ARPC2

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (cross-linking study, cross-linking study, cross-linking study, biochemical)
HPRD (in vitro)

		ACTR3	ARPC2
Description		actin related protein 3	actin related protein 2/3 complex subunit 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Site Of Double-strand Break Cell Projection Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Synaptic Vesicle Membrane Cell Leading Edge Site Of Double-strand Break Muscle Cell Projection Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cell Projection Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Actin Polymerization-dependent Cell Motility Cellular Response To Type II Interferon	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Inflammatory bowel disease ( 23128233 28067908) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 25096241 29403010)
Interacting Genes		18 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN ERCC6 HCLS1 JUND LINC01554 OGT SHARPIN UBE3A WASF2 WASF3 WASL	8 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B NFE2L2 SHANK3 WAS
Entrez ID		10096	10109
HPRD ID		05024	10367
Ensembl ID		ENSG00000115091	ENSG00000163466
Uniprot IDs		B4DXW1 P61158	O15144 Q53R19
PDB IDs		6UHC 6YW6 6YW7 8P94	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Actin Filament Organization Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Actin Nucleation Regulation Of Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Binding Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Actin Cytoskeleton Organization Glutamatergic Synapse Cytoskeleton Actin Filament Binding Structural Constituent Of Cytoskeleton Site Of Double-strand Break Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Protein Polymerization Positive Regulation Of Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Regulation Of Organelle Organization Positive Regulation Of Cell Projection Organization Cell Projection Assembly Cell Projection Regulation Of Plasma Membrane Bounded Cell Projection Organization Postsynapse Focal Adhesion	Actin Binding Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Actin Nucleation Regulation Of Lamellipodium Organization Supramolecular Fiber Organization Actin Filament Binding Actin Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Site Of Double-strand Break Structural Constituent Of Cytoskeleton Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytoskeleton Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cytosol Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Actin Polymerization Or Depolymerization Positive Regulation Of Glutathione Biosynthetic Process Regulation Of T Cell Antigen Processing And Presentation Tubulobulbar Complex Actin Filament Branching Regulation Of Smooth Muscle Cell Migration Cellular Response To Type II Interferon Negative Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Organization Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Negative Regulation Of Locomotion Regulation Of Glutathione Biosynthetic Process Regulation Of Proteolysis Positive Regulation Of Cell Projection Organization
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