ACTR3 and HCLS1

Number of citations of the paper that reports this interaction (PubMedID 12534372)
45

Data Source:
BioGRID (pull down)

		ACTR3	HCLS1
Description		actin related protein 3	hematopoietic cell-specific Lyn substrate 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Site Of Double-strand Break Cell Projection Extracellular Exosome	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cell Projection Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Actin Polymerization-dependent Cell Motility Cellular Response To Type II Interferon	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Intracellular Signal Transduction Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN ERCC6 HCLS1 JUND LINC01554 OGT SHARPIN UBE3A WASF2 WASF3 WASL	25 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CRYAA CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		10096	3059
HPRD ID		05024	03199
Ensembl ID		ENSG00000115091	ENSG00000180353
Uniprot IDs		B4DXW1 P61158	E7EVW7 P14317
PDB IDs		6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Actin Filament Organization Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Actin Nucleation Regulation Of Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Binding Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Actin Cytoskeleton Organization Glutamatergic Synapse Cytoskeleton Actin Filament Binding Structural Constituent Of Cytoskeleton Site Of Double-strand Break Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Protein Polymerization Positive Regulation Of Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Regulation Of Organelle Organization Positive Regulation Of Cell Projection Organization Cell Projection Assembly Cell Projection Regulation Of Plasma Membrane Bounded Cell Projection Organization Postsynapse Focal Adhesion	B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Actin Cytoskeleton Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Meiotic Chromosome Movement Towards Spindle Pole B Cell Homeostasis Immune Response-activating Signaling Pathway Regulation Of Mast Cell Degranulation B Cell Receptor Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Lamellipodium Assembly Positive Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Actin Filament Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Meiotic Cytokinesis Fc Receptor Signaling Pathway Arp2/3 Protein Complex Negative Regulation Of Immune System Process Lymphocyte Homeostasis Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Type II Interferon Asymmetric Cell Division Regulation Of Autophagy Leukocyte Homeostasis Immune Response Positive Regulation Of Mast Cell Degranulation Chromosome Localization Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Immune Response Innate Immune Response Negative Regulation Of B Cell Proliferation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Cellular Component Organization
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