ARPC5 and ARPC1B

Number of citations of the paper that reports this interaction (PubMedID 11721045)
0

Data Source:
HPRD (in vitro)

		ARPC5	ARPC1B
Description		actin related protein 2/3 complex subunit 5	actin related protein 2/3 complex subunit 1B
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Cortical Cytoskeleton Secretory Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Response To Estrogen
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			Alcohol consumption ( 31358974) Facial emotion recognition (sad faces) ( 28608620) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		6 interacting genes: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1	11 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA CEBPA PAK1 SRPK2 WAS
Entrez ID		10092	10095
HPRD ID		11969	10366
Ensembl ID		ENSG00000162704	ENSG00000130429
Uniprot IDs		O15511	A4D275 O15143
PDB IDs		6UHC 6YW7	6UHC 6YW6 8P94
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Actin Filament Binding Meiotic Chromosome Movement Towards Spindle Pole Actin Filament Organization Actin Cytoskeleton Meiotic Cytokinesis Actin Binding Site Of Double-strand Break Asymmetric Cell Division Supramolecular Fiber Organization Cytoskeleton Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Extracellular Exosome Regulation Of Lamellipodium Organization Spindle Localization Cellular Response To Type II Interferon Focal Adhesion Nuclear Glucocorticoid Receptor Activity Cell Division Tubulobulbar Complex Chromosome Localization Cytoskeleton-dependent Cytokinesis Response To Type II Interferon Response To Cytokine Response To Peptide Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Cell Cycle Cytosol Establishment Or Maintenance Of Cell Polarity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Actin Cap Nuclear Receptor-mediated Corticosteroid Signaling Pathway Response To Lipid Steroid Hormone Binding Calcium-dependent Protein Serine/threonine Kinase Activity Response To Cortisol Macropinocytosis Actin Polymerization-dependent Cell Motility Nucleus Regulation Of Cell Projection Assembly Mammary Gland Duct Morphogenesis Microglia Differentiation Cilium Assembly Regulation Of Glucocorticoid Biosynthetic Process Cellular Response To Growth Factor Stimulus	Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Site Of Double-strand Break Actin Cytoskeleton Actin Filament Supramolecular Fiber Organization Actin Filament Organization Actin Filament Polymerization Cytoskeleton Regulation Of Lamellipodium Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Filament-based Process Focal Adhesion Lamellipodium Actin Polymerization Or Depolymerization Cell Projection Actin Filament Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Presynapse Positive Regulation Of DNA Recombination Protein Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Cytokine Regulation Of Actin Filament Organization Response To Peptide Positive Regulation Of Double-strand Break Repair Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Projection Organization Cellular Component Assembly Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Cytosol Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of DNA Recombination Positive Regulation Of DNA Repair
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