ARPC5 and ACTR3

Number of citations of the paper that reports this interaction (PubMedID 11741539)
0

Data Source:
HPRD (in vivo)

		ARPC5	ACTR3
Description		actin related protein 2/3 complex subunit 5	actin related protein 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Cortical Cytoskeleton Secretory Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Site Of Double-strand Break Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cell Projection Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Actin Polymerization-dependent Cell Motility Cellular Response To Type II Interferon
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1	18 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN ERCC6 HCLS1 JUND LINC01554 OGT SHARPIN UBE3A WASF2 WASF3 WASL
Entrez ID		10092	10096
HPRD ID		11969	05024
Ensembl ID		ENSG00000162704	ENSG00000115091
Uniprot IDs		O15511	B4DXW1 P61158
PDB IDs		6UHC 6YW7	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Actin Filament Binding Meiotic Chromosome Movement Towards Spindle Pole Actin Filament Organization Actin Cytoskeleton Meiotic Cytokinesis Actin Binding Site Of Double-strand Break Asymmetric Cell Division Supramolecular Fiber Organization Cytoskeleton Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Extracellular Exosome Regulation Of Lamellipodium Organization Spindle Localization Cellular Response To Type II Interferon Focal Adhesion Nuclear Glucocorticoid Receptor Activity Cell Division Tubulobulbar Complex Chromosome Localization Cytoskeleton-dependent Cytokinesis Response To Type II Interferon Response To Cytokine Response To Peptide Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Cell Cycle Cytosol Establishment Or Maintenance Of Cell Polarity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Actin Cap Nuclear Receptor-mediated Corticosteroid Signaling Pathway Response To Lipid Steroid Hormone Binding Calcium-dependent Protein Serine/threonine Kinase Activity Response To Cortisol Macropinocytosis Actin Polymerization-dependent Cell Motility Nucleus Regulation Of Cell Projection Assembly Mammary Gland Duct Morphogenesis Microglia Differentiation Cilium Assembly Regulation Of Glucocorticoid Biosynthetic Process Cellular Response To Growth Factor Stimulus	Arp2/3 Protein Complex Actin Filament Organization Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Actin Nucleation Regulation Of Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Binding Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Actin Cytoskeleton Organization Glutamatergic Synapse Cytoskeleton Actin Filament Binding Structural Constituent Of Cytoskeleton Site Of Double-strand Break Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Protein Polymerization Positive Regulation Of Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Regulation Of Organelle Organization Positive Regulation Of Cell Projection Organization Cell Projection Assembly Cell Projection Regulation Of Plasma Membrane Bounded Cell Projection Organization Postsynapse Focal Adhesion
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