SKAP2

Name	src kinase associated phosphoprotein 2
Structure
Interactors	20 interactors: APP BLK DNAJB6 EEIG1 FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation
Pathways	Signal regulatory protein family interactions
GWAS	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic venous disease ( 28374850 ) Disease free survival in colon cancer ( 31811950 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) FEV1 ( 30804560 ) Hip index ( 34021172 ) Lung function (FVC) ( 30804560 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Macular thickness ( 30535121 ) Peak expiratory flow ( 30804560 ) Small cell lung carcinoma ( 28604730 ) Survival in colon cancer ( 31811950 ) Systemic lupus erythematosus ( 28714469 )
Entrez ID	8935
HPRD ID	05558
Ensembl ID	ENSG00000005020
Uniprot IDs	B7Z5R3 O75563
PDB IDs	3OMH
GO Terms Enriched among Interactors ?	Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Immune System Process Protein Phosphorylation Regulation Of Immune Response Phosphorylation Membrane Raft Protein Autophosphorylation Signaling Receptor Activator Activity Antigen Receptor-mediated Signaling Pathway Integrin-mediated Signaling Pathway Signal Transduction T Cell Costimulation Phosphotyrosine Residue Binding Negative Regulation Of Immune Response Ephrin Receptor Signaling Pathway ATP Binding Immune Effector Process Positive Regulation Of Intracellular Signal Transduction Cellular Developmental Process Negative Regulation Of Defense Response Regulation Of Transport Ephrin Receptor Binding Negative Regulation Of Inflammatory Response Nucleotide Binding Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process