SKAP2 and FRK

Number of citations of the paper that reports this interaction (PubMedID 29568343)
46

Data Source:
BioGRID (protein complementation assay)

		SKAP2	FRK
Description		src kinase associated phosphoprotein 2	fyn related Src family tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Symbiont-mediated Suppression Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Innate Immune Response
Pathways		Signal regulatory protein family interactions	Neutrophil degranulation Regulation of PTEN stability and activity
Drugs			Dasatinib Regorafenib Fostamatinib Zanubrutinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Hip index ( 34021172) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)	Age-related macular degeneration ( 21665990) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 28724990) Aspartate aminotransferase levels ( 34315874 33547301) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) High density lipoprotein cholesterol levels ( 33339817) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Low density lipoprotein cholesterol levels ( 32154731) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 28334899) Urate levels ( 23263486)
Interacting Genes		20 interacting genes: APP BLK DNAJB6 EEIG1 FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1	6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2
Entrez ID		8935	2444
HPRD ID		05558	05954
Ensembl ID		ENSG00000005020	ENSG00000111816
Uniprot IDs		B7Z5R3 O75563	P42685
PDB IDs		3OMH
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Immune System Process Protein Phosphorylation Regulation Of Immune Response Phosphorylation Membrane Raft Protein Autophosphorylation Signaling Receptor Activator Activity Antigen Receptor-mediated Signaling Pathway Integrin-mediated Signaling Pathway Signal Transduction T Cell Costimulation Phosphotyrosine Residue Binding Negative Regulation Of Immune Response Ephrin Receptor Signaling Pathway ATP Binding Immune Effector Process Positive Regulation Of Intracellular Signal Transduction Cellular Developmental Process Negative Regulation Of Defense Response Regulation Of Transport Ephrin Receptor Binding Negative Regulation Of Inflammatory Response Nucleotide Binding Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process	Epithelial Cell Proliferation Embryonic Placenta Development Neuron Differentiation Sebum Secreting Cell Proliferation Regulation Of Cell Population Proliferation Embryonic Organ Development Cell Population Proliferation Regulation Of NK T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Striated Muscle Cell Differentiation Regulation Of Programmed Cell Death Muscle Cell Differentiation Regulation Of Apoptotic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Kinase Binding Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Myofibroblast Differentiation Mitotic Cell Cycle Phase Transition Sister Chromatid Biorientation Cell Cycle G1/S Phase Transition Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Cell Cycle Phase Transition Positive Regulation Of Collagen Fibril Organization Splicing Factor Binding Positive Regulation Of RNA Export From Nucleus Grb2-Sos Complex Enucleate Erythrocyte Differentiation ERBB2-EGFR Signaling Pathway Cyclin/CDK Positive Transcription Elongation Factor Complex Retinal Bipolar Neuron Differentiation Maternal Placenta Development Developmental Process Involved In Reproduction
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