SKAP2 and HCK

Number of citations of the paper that reports this interaction (PMID 9837776)
5

Data Source:
HPRD (in vivo)

		SKAP2	HCK
Gene Name		src kinase associated phosphoprotein 2	HCK proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Lysosome Golgi Apparatus Cytosol Actin Filament Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Protein Complex Assembly Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction B Cell Activation	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signal regulatory protein (SIRP) family interactions	HIV Infection Host Interactions of HIV factors Cytokine Signaling in Immune system The role of Nef in HIV-1 replication and disease pathogenesis Nef and signal transduction Signaling by Interleukins Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Interleukin-3, 5 and GM-CSF signaling FCGR activation Innate Immune System
Drugs			1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		11 interactors: APP FASLG FYB FYN HCK KHDRBS1 LYN PRAM1 PTK2B SRC TGFBR1	69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2
Entrez ID		8935	3055
HPRD ID		05558	00796
Ensembl ID		ENSG00000005020	ENSG00000101336
Uniprot IDs		B7Z5N4 B7Z5R3 O75563	A8K4G3 P08631
PDB IDs		3OMH	1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Immune System Process Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Locomotion Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Signal Transduction Regulation Of Apoptotic Process Cell Migration Response To Lipid Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Intracellular Transport Regulation Of Cell Death Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of Immune System Process Signaling Immune Response-regulating Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Cell Projection Organization Cell Communication Regulation Of Extrinsic Apoptotic Signaling Pathway Platelet Activation Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Lipid Kinase Activity Cell Development Response To External Stimulus Leukocyte Migration Phosphate-containing Compound Metabolic Process Neuron Differentiation Wound Healing	Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Blood Coagulation Response To Stimulus Defense Response Regulation Of Immune Response Hemostasis Wound Healing Immune System Process Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Antigen Receptor-mediated Signaling Pathway Response To Wounding Positive Regulation Of Immune Response Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Body Fluid Levels Locomotion Regulation Of Immune System Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Vesicle-mediated Transport Response To Stress Regulation Of Signal Transduction Regulation Of Cellular Process Platelet Activation Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Signaling Response To External Stimulus Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process
Tagcloud ?			32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam
Tagcloud (Difference) ?			32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam
Tagcloud (Intersection) ?