BLOC1S2 and FAM161B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BLOC1S2	FAM161B
Description		biogenesis of lysosomal organelles complex 1 subunit 2	FAM161 centrosomal protein B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Centrosome Cytosol Cytoskeleton Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm	Cytoskeleton Cytoplasmic Microtubule Microtubule Cytoskeleton
	Molecular Function	Protein Binding Gamma-tubulin Binding	Protein Binding
	Biological Process	Microtubule Nucleation Anterograde Axonal Transport Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Endosomal Transport Neuron Projection Development Lysosome Localization Melanosome Organization Positive Regulation Of DNA-templated Transcription Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Platelet Dense Granule Organization Regulation Of Lysosome Size Organelle Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization	Cilium Organization
Pathways
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Serum uric acid levels ( 29559957)
Interacting Genes		36 interacting genes: APP ARFIP2 BFSP2 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 C8orf33 CCDC146 CCHCR1 CCNC CTNNA3 DCTN2 ERP27 EXOC8 FAM161B FAM9B GADD45G GEM HMOX2 KRT26 MEST P4HA3 PAM16 PICK1 RDH11 SH2D4A SNAPIN SSC5D STX2 TNNT1 TRIML2 TTC3 WASHC1 WASHC3	70 interacting genes: ABI2 BICD2 BLOC1S2 BORCS6 CARD9 CBY1 CCDC125 CCDC13 CCDC136 CCDC138 CCDC172 CCDC57 CCDC83 CCDC88B CDR2L CEP55 CEP70 CINP CTNNA3 DDI1 DRC4 EXOSC8 GOLGA2 GOLGA6A GOLGA6L9 GPSM1 HAUS1 HOMER3 HOOK2 HSF2BP ISY1-RAB43 KIAA1328 LZTS1 MAPRE3 MDFI MEIS3 MID2 MIPOL1 MTUS2 NDUFB7 NECAB2 NR3C1 OIP5 PICK1 PLAGL2 PNMA1 PPP2R3C RINT1 SH3BP5L SMAD2 SPDEF SRGAP2B STX11 STX1B SYCE1 TEX11 TEX12 TFIP11 TRAF1 TRAF2 TRIM15 TSGA10 TSNAXIP1 TTC23 TTC23L USH1G USHBP1 VPS52 ZC4H2 ZRANB1
Entrez ID		282991	145483
HPRD ID		12526	12649
Ensembl ID		ENSG00000196072	ENSG00000156050
Uniprot IDs		A0A087X1N6 F1T0F0 Q6QNY1	Q96MY7
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterograde Synaptic Vesicle Transport BLOC-1 Complex Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Axo-dendritic Transport Anterograde Axonal Transport Vesicle Transport Along Microtubule Vesicle Cytoskeletal Trafficking Establishment Of Vesicle Localization Axon Cytoplasm Axonal Transport Vesicle Localization Organelle Localization Organelle Transport Along Microtubule Intracellular Transport Transport Along Microtubule Melanosome Transport Cellular Localization Establishment Of Melanosome Localization Pigment Granule Transport Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Melanosome Localization Pigment Granule Localization Vesicle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Microtubule-based Transport Microvesicle Regulation Of Actin Nucleation Plasma Membrane Bounded Cell Projection Organization Endosome To Melanosome Transport Microtubule-based Movement Establishment Of Organelle Localization Protein Transport Cell Projection Organization Secretion By Cell Organelle Organization Membrane Curvature Sensor Activity Microtubule-based Process Establishment Of Protein Localization Secretion Of Lysosomal Enzymes Neuron Projection Development Exocytosis Positive Regulation Of Pigment Cell Differentiation Secretion Regulation Of Lysosome Size BORC Complex Positive Regulation Of Developmental Pigmentation Pigmentation	Cytoskeleton Centrosome Identical Protein Binding Microtubule Cytoskeleton Organization Organelle Organization Microtubule-based Process Central Element Protein Binding Cytoskeleton Organization Cytoplasm Microtubule Binding Synaptonemal Complex Assembly Synaptonemal Complex Synaptonemal Complex Organization Cytoskeleton-dependent Intracellular Transport Dynein Light Intermediate Chain Binding Microtubule Nucleation Signaling Adaptor Activity Organelle Transport Along Microtubule Regulation Of Lysosome Size BORC Complex Microtubule Cell Division Organelle Localization Thioesterase Binding Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Golgi Cis Cisterna Vesicle Fusion To Plasma Membrane Regulation Of Endosome Size
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